Evidence map›Paper›PMID 25448264›Full record

ReviewInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2015

The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies.

Chella Kamarajan, Ashwini K Pandey, David B Chorlian, Bernice Porjesz

Open access · greenAbstract readReview
In one paragraph

Review in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Audiovisual integration facilitates age-related perceptual decision making.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
    Article
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  6. Novel methodology for detection and prediction of mild cognitive impairment using resting-state EEG.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  7. Article
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  11. Brain Functional Network and Amino Acid Metabolism Association in Females with Subclinical Depression.International journal of environmental research and public health · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Using Event-Related Potentials and Startle to Evaluate Time Course in Anxiety and Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018
    Review
  18. Article
  19. Article
  20. Genetic influences on functional connectivity associated with feedback processing and prediction error: Phase coupling of theta-band oscillations in twins.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Chella KamarajanHenri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA. Electronic address: kam@hbnl.downstate.edu.
Ashwini K PandeyHenri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.
David B ChorlianHenri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.
Bernice PorjeszHenri Begleiter Neurodynamics Laboratory, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.
SUNY Downstate Health Sciences University · US

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JESSICA E SALVATORE · 1989 to 2026
$162.7M
BRAIN DYSFUNCTION AND ALCOHOLISMR01AA002686 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI PORJESZ, BERNICE · 1985 to 2018
$9.6M
NEUROPHYSIOLOGY IN CHILDREN AT HIGH RISK FOR ALCOHOLISMR01AA005524 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI PORJESZ, BERNICE · 1986 to 2015
$3.0M
NIAAA NIH HHS R01 AA002686NIAAA NIH HHS R01 AA005524NIAAA NIH HHS R01 AA02686-37NIAAA NIH HHS R01 AA05524-29NIAAA NIH HHS U10 AA008401NIAAA NIH HHS U10 AA008401-26
6 · The paper itself

Abstract

The use of current source density (CSD), the Laplacian of the scalp surface voltage, to map the electrical activity of the brain is a powerful method in studies of cognitive and affective phenomena. During the last few decades, mapping of CSD has been successfully applied to characterize several neuropsychiatric conditions such as alcoholism, schizophrenia, depression, anxiety disorders, childhood/developmental disorders, and neurological conditions (i.e., epilepsy and brain lesions) using electrophysiological data from resting state and during cognitive performance. The use of CSD and Laplacian measures has proven effective in elucidating topographic and activation differences between groups: i) patients with a specific diagnosis vs. healthy controls, ii) subjects at high risk for a specific diagnosis vs. low risk or normal controls, and iii) patients with specific symptom(s) vs. patients without these symptom(s). The present review outlines and summarizes the studies that have employed CSD measures in investigating several neuropsychiatric conditions. The advantages and potential of CSD-based methods in clinical and research applications along with some of the limitations inherent in the CSD-based methods are discussed in the review, as well as future directions to expand the implementation of CSD to other potential clinical applications. As CSD methods have proved to be more advantageous than using scalp potential data to understand topographic and source activations, its clinical applications offer promising potential, not only for a better understanding of a range of psychiatric conditions, but also for a variety of focal neurological disorders, including epilepsy and other conditions involving brain lesions and surgical interventions.

Indexed as

Brain MappingElectrophysiologyElectrophysiological PhenomenaHumansMental DisordersNervous System DiseasesAlcohol use disordersBrain lesionsChildhood disordersCurrent source density (CSD)DepressionEEGEpilepsyEvent-related potentials (ERPs)Neural generatorsNeurocognitive deficitsNeuropsychiatric disordersSchizophreniaSurface Laplacian

Identifiers

PMID25448264
PMCPMC4422780
OpenAlexW2117631549

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.