ArticleGeneral and comparative endocrinology2015
Perchlorate disrupts embryonic androgen synthesis and reproductive development in threespine stickleback without changing whole-body levels of thyroid hormone.
Article in General and comparative endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Transcriptomic and developmental effects of persistent organic pollutants in sentinel fishes collected near an arctic formerly used defense site.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Differential gene expression and developmental pathologies associated with persistent organic pollutants in sentinel fish in Troutman Lake, Sivuqaq, Alaska.Environmental pollution (Barking, Essex : 1987) · 2024Article
- Evaluating Dermal Bone as a Novel Source of Endocrine Information in Ninespine and Threespine Stickleback Fish.Integrative organismal biology (Oxford, England) · 2023Article
- Sexually mediated phenotypic variation within and between sexes as a continuum structured by ecology: The mosaic nature of skeletal variation across body regions in Threespine stickleback (Ecology and evolution · 2022Article
- Evolution and developmental expression of the sodium-iodide symporter (Evolutionary applications · 2022Article
- Health Impacts of Perchlorate and Pesticide Exposure: Protocol for Community-Engaged Research to Evaluate Environmental Toxicants in a US Border Community.JMIR research protocols · 2021Article
- Developmental assays using invasive cane toads, Rhinella marina, reveal safety concerns of a common formulation of the rice herbicide, butachlor.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Perchlorate exposure does not induce obesity or non-alcoholic fatty liver disease in zebrafish.PloS one · 2021Article
- Sodium perchlorate induces non-alcoholic fatty liver disease in developing stickleback.Environmental pollution (Barking, Essex : 1987) · 2019Article
- Ecotoxicological assessment of perchlorate using in vitro and in vivo assays.Environmental science and pollution research international · 2018Article
- Endocrine disruption and differential gene expression in sentinel fish on St. Lawrence Island, Alaska: Health implications for indigenous residents.Environmental pollution (Barking, Essex : 1987) · 2018Article
- Heterochronic development of lateral plates in the three-spined stickleback induced by thyroid hormone level alterations.PloS one · 2018Article
- Uncertainties in biological responses that influence hazard and risk approaches to the regulation of endocrine active substances.Integrated environmental assessment and management · 2017Article
- Exogenous iodide ameliorates perchlorate-induced thyroid phenotypes in threespine stickleback.General and comparative endocrinology · 2017Article
- Perchlorate Exposure Reduces Primordial Germ Cell Number in Female Threespine Stickleback.PloS one · 2016Article
- Developmental timing of sodium perchlorate exposure alters angiogenesis, thyroid follicle proliferation and sexual maturation in stickleback.General and comparative endocrinology · 2015Article
- Perchlorate exposure does not modulate temporal variation of whole-body thyroid and androgen hormone content in threespine stickleback.General and comparative endocrinology · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Perchlorate, an environmental contaminant, disrupts normal functioning of the thyroid. We previously showed that perchlorate disrupts behavior and gonad development, and induces external morphological changes in a vertebrate model organism, the threespine stickleback. Whether perchlorate alters these phenotypes via a thyroid-mediated mechanism, and the extent to which the effects depend on dose, are unknown. To address these questions, we chronically exposed stickleback to control conditions and to three concentrations of perchlorate (10, 30 and 100ppm) at various developmental stages from fertilization to reproductive maturity. Adults chronically exposed to perchlorate had increased numbers of thyroid follicles and decreased numbers of thyrocytes. Surprisingly, T4 and T3 levels in larval, juvenile, and adult whole fish chronically exposed to perchlorate did not differ from controls, except at the lowest perchlorate dose, suggesting a non-monotonic dose response curve. We found no detectable abnormalities in external phenotype at any dose of perchlorate, indicating that the increased number of thyroid follicles compensated for the disruptive effects of these doses. In contrast to external morphology, gonadal development was altered substantially, with the highest dose of perchlorate causing the largest effects. Perchlorate increased the number both of early stage ovarian follicles in females and of advanced spermatogenic stages in males. Perchlorate also disrupted embryonic androgen levels. We conclude that chronic perchlorate exposure may not result in lasting adult gross morphological changes but can produce lasting modifications to gonads when compensation of T3 and T4 levels occurs by thyroid follicle hyperplasia. Perchlorate may therefore affect vertebrate development via both thyroidal and non-thyroidal mechanisms.
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