ReviewBiochimica et biophysica acta2015
Combining solvent isotope effects with substrate isotope effects in mechanistic studies of alcohol and amine oxidation by enzymes.
Review in Biochimica et biophysica acta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed.
- Mechanistic and spectroscopic characterization of human CYP17A1 in Nanodiscs.Journal of inorganic biochemistry · 2026Review
- Metal-Triggered FAD Reduction in d-2-Hydroxyglutarate Dehydrogenase fromACS bio & med chem Au · 2025Article
- Reaction contest: hydrolysisRSC advances · 2024Article
- Replacement of Tyrosines by Unnatural Amino Acid Aminophenylalanine Leads to Metal-Mediated Aniline Free Radical Formation in a Copper Amine Oxidase.ACS chemical biology · 2024Article
- Pyridine-based strategies towards nitrogen isotope exchange and multiple isotope incorporation.Nature communications · 2024Article
- Interplay of structural preorganization and conformational sampling in UDP-glucuronic acid 4-epimerase catalysis.Nature communications · 2024Article
- Solvent isotope and mutagenesis studies on the proton relay system in yeast alcohol dehydrogenase 1.Chemico-biological interactions · 2024Article
- The Pseudomonas aeruginosa PAO1 metallo flavoprotein d-2-hydroxyglutarate dehydrogenase requires ZnThe Journal of biological chemistry · 2023Article
- Reversibility and Low Commitment to Forward Catalysis in the Conjugation of Lipid Alkenals by Glutathione Transferase A4-4.Biomolecules · 2023Article
- Hydride Transfer Mechanism of Enzymatic Sugar Nucleotide C2 Epimerization Probed with a Loose-Fit CDP-Glucose Substrate.ACS catalysis · 2022Article
- A Kinetic Isotope Effect in the Formation of Lanthanide Phosphate Nanocrystals.Journal of the American Chemical Society · 2022Article
- Computational Analysis of the Nicotine Oxidoreductase Mechanism by the ONIOM Method.ACS omega · 2021Article
- Temperature-Dependent Kinetic Isotope Effects in R67 Dihydrofolate Reductase from Path-Integral Simulations.The journal of physical chemistry. B · 2021Article
- pH and deuterium isotope effects on the reaction of trimethylamine dehydrogenase with dimethylamine.Archives of biochemistry and biophysics · 2019Article
- A bio-inspired coordination polymer as outstanding water oxidation catalyst via second coordination sphere engineering.Nature communications · 2019Article
- Mechanism of the Flavoprotein d-6-Hydroxynicotine Oxidase: Substrate Specificity, pH and Solvent Isotope Effects, and Roles of Key Active-Site Residues.Biochemistry · 2019Article
- Structure and role for active site lid of lactate monooxygenase from Mycobacterium smegmatis.Protein science : a publication of the Protein Society · 2019Article
- Nitroalkane oxidase: Structure and mechanism.Archives of biochemistry and biophysics · 2017Review
- Mechanistic Studies of an Amine Oxidase Derived from d-Amino Acid Oxidase.Biochemistry · 2017Article
- Mechanism of Flavoprotein l-6-Hydroxynicotine Oxidase: pH and Solvent Isotope Effects and Identification of Key Active Site Residues.Biochemistry · 2017Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Oxidation of alcohols and amines is catalyzed by multiple families of flavin- and pyridine nucleotide-dependent enzymes. Measurement of solvent isotope effects provides a unique mechanistic probe of the timing of the cleavage of the OH and NH bonds, necessary information for a complete description of the catalytic mechanism. The inherent ambiguities in interpretation of solvent isotope effects can be significantly decreased if isotope effects arising from isotopically labeled substrates are measured in combination with solvent isotope effects. The application of combined solvent and substrate (mainly deuterium) isotope effects to multiple enzymes is described here to illustrate the range of mechanistic insights that such an approach can provide. This article is part of a Special Issue entitled: Enzyme Transition States from Theory and Experiment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.