ArticleExperimental neurology2015
Hypoxia triggers short term potentiation of phrenic motoneuron discharge after chronic cervical spinal cord injury.
Article in Experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Pairing ampakine with brief hypoxia evokes phrenic neuroplasticity via a spinal NMDA receptor-mediated mechanism.Function (Oxford, England) · 2026Article
- Article
- Ampakines increase diaphragm activation following mid-cervical contusion injury in rats.Experimental neurology · 2024Article
- Pattern sensitivity of ampakine-hypoxia interactions for evoking phrenic motor facilitation in anesthetized rat.Journal of neurophysiology · 2024Article
- Effects of C2 hemisection on respiratory and cardiovascular functions in rats.Neural regeneration research · 2023Article
- MiR-495 regulates cell proliferation and apoptosis in HAnnals of translational medicine · 2021Article
- Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation.Communications biology · 2021Article
- Mid-cervical interneuron networks following high cervical spinal cord injury.Respiratory physiology & neurobiology · 2020Article
- Pharmacological modulation of hypoxia-induced respiratory neuroplasticity.Respiratory physiology & neurobiology · 2018Review
- High-frequency epidural stimulation across the respiratory cycle evokes phrenic short-term potentiation after incomplete cervical spinal cord injury.Journal of neurophysiology · 2017Article
- The crossed phrenic phenomenon.Neural regeneration research · 2017Review
- Intraspinal microstimulation and diaphragm activation after cervical spinal cord injury.Journal of neurophysiology · 2017Article
- Phrenic motor outputs in response to bronchopulmonary C-fibre activation following chronic cervical spinal cord injury.The Journal of physiology · 2016Article
- Tetraplegia is associated with enhanced peripheral chemoreflex sensitivity and ventilatory long-term facilitation.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
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Authors and funding
5 authors.
Funding
Abstract
Repeated exposure to hypoxia can induce spinal neuroplasticity as well as respiratory and somatic motor recovery after spinal cord injury (SCI). The purpose of the present study was twofold: to define the capacity for a single bout of hypoxia to trigger short-term plasticity in phrenic output after cervical SCI and to determine the phrenic motoneuron (PhrMN) bursting and recruitment patterns underlying the response. Hypoxia-induced short term potentiation (STP) of phrenic motor output was quantified in anesthetized rats 11 weeks following lateral spinal cord hemisection at C2 (C2Hx). A 3-min hypoxic episode (12-14% O2) always triggered STP of inspiratory burst amplitude, the magnitude of which was greater in phrenic bursting ipsilateral vs. contralateral to C2Hx. We next determined if STP could be evoked in recruited (silent) PhrMNs ipsilateral to C2Hx. Individual PhrMN action potentials were recorded during and following hypoxia using a "single fiber" approach. STP of bursting activity did not occur in cells initiating bursting at inspiratory onset, but was robust in recruited PhrMNs as well as previously active cells initiating bursting later in the inspiratory effort. We conclude that following chronic C2Hx, a single bout of hypoxia triggers recruitment of PhrMNs in the ipsilateral spinal cord with bursting that persists beyond the hypoxic exposure. The results provide further support for the use of short bouts of hypoxia as a neurorehabilitative training modality following SCI.
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