Evidence map›Paper›PMID 25447545›Full record

ReviewBiochimica et biophysica acta2015

Recent advances in the Suf Fe-S cluster biogenesis pathway: Beyond the Proteobacteria.

F Wayne Outten

Abstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 78 citations in OpenAlex.

  1. Biogenic Selenium Nanoparticles from Food-GradeFoods (Basel, Switzerland) · 2026
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  4. Protein-centric mechanisms of typhoidalFrontiers in cellular and infection microbiology · 2026
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  5. SmsB-SmsC machinery inApplied and environmental microbiology · 2025
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  6. RadicalNature catalysis · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

F Wayne OuttenUniversity of South Carolina, Department of Chemistry and Biochemistry, 631 Sumter Street, Columbia, SC 29208, USA. Electronic address: outtenf@mailbox.sc.edu.
University of South Carolina · US

Funding

Characterization of the Suf Fe-S Cluster Biosynthesis Pathway Under StressR01GM081706 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI OUTTEN, FRANKLIN WAYNE · 2007 to 2011
$1.1M
NIGMS NIH HHS GM81706NIGMS NIH HHS R01 GM081706
6 · The paper itself

Abstract

Fe-S clusters play critical roles in cellular function throughout all three kingdoms of life. Consequently, Fe-S cluster biogenesis systems are present in most organisms. The Suf (sulfur formation) system is the most ancient of the three characterized Fe-S cluster biogenesis pathways, which also include the Isc and Nif systems. Much of the first work on the Suf system took place in Gram-negative Proteobacteria used as model organisms. These early studies led to a wealth of biochemical, genetic, and physiological information on Suf function. From those studies we have learned that SufB functions as an Fe-S scaffold in conjunction with SufC (and in some cases SufD). SufS and SufE together mobilize sulfur for cluster assembly and SufA traffics the complete Fe-S cluster from SufB to target apo-proteins. However, recent progress on the Suf system in other organisms has opened up new avenues of research and new hypotheses about Suf function. This review focuses primarily on the most recent discoveries about the Suf pathway and where those new models may lead the field. This article is part of a Special Issue entitled: Fe/S proteins: Analysis, structure, function, biogenesis and diseases.

Indexed as

Biosynthetic PathwaysBacillus subtilisBacterial ProteinsEscherichia coliIron-Sulfur ProteinsModels, MolecularProtein BindingProtein Structure, TertiaryProteobacteriaSulfurBacterial ProteinsIron-Sulfur ProteinsSulfurB. subtilisFe–S clusterIron–SulfurIscPlasmodiumSuf

Identifiers

PMID25447545
PMCPMC4390423
OpenAlexW2004221349

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.