Evidence map›Paper›PMID 25447523›Full record

ArticleFEBS letters2014

Calcium release-activated calcium (CRAC) channels mediate the β(2)-adrenergic regulation of Na,K-ATPase.

Michael J Keller, Emilia Lecuona, Murali Prakriya, Yuan Cheng, Saul Soberanes, G R Scott Budinger, Jacob I Sznajder

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Michael J KellerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Emilia LecuonaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: e-lecuona@northwestern.edu.
Murali PrakriyaDepartment of Molecular Pharmacology and Biological Chemistry, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Yuan ChengDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Saul SoberanesDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
G R Scott BudingerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Jacob I SznajderDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Northwestern University · US

Funding

Role of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2003 to 2019
$30.8M
Training Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6M
Store-Operated Channels in the Nervous SystemR01NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2007 to 2022
$5.4M
Role and Regulation of Sodium, Potasium ATPase in LungR37HL048129 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2008 to 2017
$4.0M
Signaling in the lung induced by particulate matter air pollutionR01ES013995 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT · 2006 to 2015
$3.3M
ROLE AND REGULATION OF SODIUM, POTASSIUM ATPASE IN LUNGR01HL048129 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 1996 to 2007
$2.7M
The Role of Mitochondrial Reactive Oxygen Species in TGF-Beta SignalingI01BX000201 · VA · JESSE BROWN VA MEDICAL CENTER · PI BUDINGER, GR SCOTT, JAIN, MANU · 2011 to 2017
–
BLRD VA I01 BX000201NHLBI NIH HHS HL48129NHLBI NIH HHS HL-71643NHLBI NIH HHS HL-76139NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL048129NHLBI NIH HHS R37 HL048129NHLBI NIH HHS T32 HL076139NIEHS NIH HHS R01 ES013995NINDS NIH HHS R01 NS057499
6 · The paper itself

Abstract

β2-Adrenergic agonists have been shown to regulate Na,K-ATPase in the alveolar epithelium by recruiting Na,K-ATPase-containing vesicles to the plasma membrane of alveolar epithelial cells (AEC). Here, we provide evidence that β2-agonists induce store-operated calcium entry (SOCE) in AECs. This calcium entry is necessary for β2-agonist-induced recruitment of Na,K-ATPase to the plasma membrane of AECs. Specifically, we show that β2-agonists induce SOCE via stromal interaction molecule 1 (STIM1)-associated calcium release-activated calcium (CRAC) channels. We also demonstrate that the magnitude of SOCE affects the abundance of Na,K-ATPase at the plasma membrane of AECs.

Indexed as

Adenylyl CyclasesAdrenergic beta-2 Receptor AntagonistsAlbuterolAnimalsCalciumCalcium-Binding ProteinsCell MembraneEnzyme ActivationEpithelial CellsIntracellular SpaceMaleMembrane GlycoproteinsProtein TransportPulmonary AlveoliRatsSodium-Potassium-Exchanging ATPaseAdenylyl CyclasesAdrenergic beta-2 Receptor AntagonistsAlbuterolCalciumCalcium-Binding ProteinsMembrane GlycoproteinsSodium-Potassium-Exchanging ATPaseStim1 protein, ratStromal Interaction Molecule 1Calcium channelCalcium signalingEpithelial cellNa,K-ATPaseStore-operated calcium entry

Identifiers

PMID25447523
PMCPMC4267986
OpenAlexW2067896855

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.