Evidence map›Paper›PMID 25447054›Full record

ReviewThe American journal of pathology2015

Pathogenesis of necrotizing enterocolitis: modeling the innate immune response.

Scott M Tanner, Taylor F Berryhill, James L Ellenburg, Tamas Jilling, Dava S Cleveland, Robin G Lorenz, Colin A Martin

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 2 syntheses or guidelines pooled it, 184 citations in OpenAlex.

  1. Pooled it
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  10. Impact of oralmSystems · 2025
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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Scott M TannerDepartment of Pediatric Surgery, University of Alabama at Birmingham, Birmingham, Alabama; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Taylor F BerryhillDepartment of Pediatric Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
James L EllenburgDepartment of Pediatric Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
Tamas JillingDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
Dava S ClevelandDepartment of Pediatric Pathology, Children's Hospital of Alabama, Birmingham, Alabama.
Robin G LorenzDepartment of Pathology, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: rlorenz@uab.edu.
Colin A MartinDepartment of Pediatric Surgery, University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: cmartin7@uab.edu.
University of Alabama at Birmingham · USChildren's of Alabama · US

Funding

INNATE AND ADAPTIVE MICROBIAL IMMUNITY IN IBDP01DK071176 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ELSON, CHARLES O · 2005 to 2014
$12.5M
Mucosal HIV and Immunobiology CenterR24DK064400 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SMITH, PHILLIP D · 2003 to 2012
$4.8M
EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT: PHYSIOLOGYC06RR020136 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MARCHASE, RICHARD BANFIELD · 2004 to 2004
$3.6M
NCRR NIH HHS C06 RR020136NCRR NIH HHS C06RR020136NIDDK NIH HHS P01 DK071176NIDDK NIH HHS P30 DK064400NIDDK NIH HHS R24 DK064400
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is a major cause of morbidity and mortality in premature infants. The pathophysiology is likely secondary to innate immune responses to intestinal microbiota by the premature infant's intestinal tract, leading to inflammation and injury. This review provides an updated summary of the components of the innate immune system involved in NEC pathogenesis. In addition, we evaluate the animal models that have been used to study NEC with regard to the involvement of innate immune factors and histopathological changes as compared to those seen in infants with NEC. Finally, we discuss new approaches to studying NEC, including mathematical models of intestinal injury and the use of humanized mice.

Indexed as

AnimalsDisease Models, AnimalEnterocolitis, NecrotizingHumansImmunity, InnateInfant, NewbornInflammationIntestinesMiceMicrobiotaModels, TheoreticalMucous MembraneNecrosisPaneth CellsRats

Identifiers

PMID25447054
PMCPMC4278236
OpenAlexW174991440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.