Evidence map›Paper›PMID 25446781›Full record

ArticleThe pharmacogenomics journal2015

Association study of UGT1A9 promoter polymorphisms with DILI based on systematically regional variation screen in Chinese population.

J Jiang, X Zhang, R Huo, X Li, Y Yang, Z Gai, M Xu, L Shen, L Cai, C Wan and 3 more

Abstract read
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In one paragraph

Article in The pharmacogenomics journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

J Jiang1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China.
X ZhangDepartment of Pharmacy, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
R Huo1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China.
X Li1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China.
Y YangGeneral Hospital of Ningxia Medical University, YinChuan, China.
Z GaiJinan Infectious Disease Hospital, Shandong University, Jinan, China.
M Xu1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China.
L Shen1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China.
L Cai1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China.
C Wan1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China.
B Li1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China.
L He1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China [3] Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai, China.
S Qin1] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China.
Shanghai Jiao Tong University · CNChinese National Human Genome Center at Shanghai · CNJinan Infectious Disease Hospital · CNNingxia Medical University General Hospital · CNShanghai Pulmonary Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-induced liver injury (DILI) is caused by unpredictable adverse drug reaction due mainly to the accumulation of hepatotoxic compounds in the liver resulting in significant damage. Drug-metabolizing enzymes have been prime targets for molecular studies relevant to DILI. The gene UGT1A9 mainly expresses in the liver and has an important role in drug metabolism. The Han Chinese has a very long and complex demographic history, and the population stratification arising from the interplay of different geographic areas may influence the polymorphism pattern. We selected 260 healthy subjects in three different geographic areas (including Xian, Shanghai and Liuzhou) for systemic screening and analysis of single-nucleotide polymorphisms (SNPs) in the promoter region of UGT1A9. Eight SNPs were identified and no regional disparity exists among the three populations. Based on these results, 213 DILI patients from all over the Chinese mainland were further recruited to investigate possible association between UGT1A9 and DILI. We observed statistically significant associations between SNP rs2741045 and DILI at both allele and genotype levels (allele: P=0.032; genotype: P=0.029; after Bonferroni correction). Also, multivariate interaction analysis discovered the interaction between rs2741045 and age associated with DILI significantly. This is the first such screening study to investigate the association between UGT1A9 promoter polymorphisms and DILI in the Chinese population and it could provide the basis for further study of DILI mechanisms.

Indexed as

AdolescentAdultAgedAged, 80 and overAllelesAsian PeopleChemical and Drug Induced Liver InjuryChildChinaDrug-Related Side Effects and Adverse ReactionsFemaleGenetic TestingGenome-Wide Association StudyGenotypeGeographyGlucuronosyltransferaseGlucuronosyltransferaseUDP-Glucuronosyltransferase 1A9UGT1A9 protein, human

Identifiers

PMID25446781
OpenAlexW2013633540

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.