Evidence map›Paper›PMID 25446554›Full record

ReviewProgress in cardiovascular diseases

Benefits of exercise training on coronary blood flow in coronary artery disease patients.

Rebecca S Bruning, Michael Sturek

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.

  1. Pooled it
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  11. New Approaches in Heart Research: Prevention Instead of Cardiomyoplasty?International journal of molecular sciences · 2023
    Review
  12. Article
  13. Article
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  15. Benefits of Cycling Wheelchair Training for Elderly with Physical Disability: A Prospective Cohort Study.International journal of environmental research and public health · 2022
    Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Rebecca S BruningDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202-5120.
Michael SturekDepartment of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202-5120. Electronic address: msturek@iupui.edu.
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

EXERCISE, DIABETES, &CORONARY SMOOTH MUSCLE Ca2+R01HL062552 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI STUREK, MICHAEL · 1999 to 2013
$4.5M
Training in Vascular Biology and MedicineT32HL079995 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARCH, KEITH LEONARD · 2005 to 2014
$2.2M
NHLBI NIH HHS R01 HL062552NHLBI NIH HHS T32 HL079995
6 · The paper itself

Abstract

Every 34 seconds an American experiences a myocardial infarction or cardiac death. Approximately 80% of these coronary artery disease (CAD)-related deaths are attributable to modifiable behaviors, such as a lack of physical exercise training (ET). Regular ET decreases CAD morbidity and mortality through systemic and cardiac-specific adaptations. ET increases myocardial oxygen demand acting as a stimulus to increase coronary blood flow and thus myocardial oxygen supply, which reduces myocardial infarction and angina. ET augments coronary blood flow through direct actions on the vasculature that improve endothelial and coronary smooth muscle function, enhancing coronary vasodilation. Additionally, ET promotes collateralization, thereby, increasing blood flow to ischemic myocardium and also treats macrovascular CAD by attenuating the progression of coronary atherosclerosis and restenosis, potentially through stabilization of atherosclerotic lesions. In summary, ET can be used as a relatively safe and inexpensive way to prevent and treat CAD.

Indexed as

Coronary CirculationExercise TherapyHemodynamicsAdaptation, PhysiologicalCollateral CirculationCoronary Artery DiseaseCoronary VesselsHumansPractice Guidelines as TopicRecovery of FunctionRegional Blood FlowRisk FactorsTreatment OutcomeCoronary artery diseaseCoronary blood flowExercise

Identifiers

PMID25446554
PMCPMC4366344
OpenAlexW2077948002

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.