Evidence map›Paper›PMID 25446441›Full record

ArticleBrain research2015

Dopamine receptor signaling in the medial orbital frontal cortex and the acquisition and expression of fructose-conditioned flavor preferences in rats.

Danielle C Malkusz, Ira Yenko, Francis M Rotella, Theodore Banakos, Kerstin Olsson, Trisha Dindyal, Vishal Vig, Richard J Bodnar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Danielle C MalkuszBehavioral and Cognitive Neuroscience Cluster, Psychology Doctoral Program, The Graduate Center, City University of New York, New York, NY, United States.
Ira YenkoDepartment of Psychology, Queens College, City University of New York, New York, NY, United States.
Francis M RotellaBehavioral and Cognitive Neuroscience Cluster, Psychology Doctoral Program, The Graduate Center, City University of New York, New York, NY, United States.
Theodore BanakosDepartment of Psychology, Queens College, City University of New York, New York, NY, United States.
Kerstin OlssonDepartment of Psychology, Queens College, City University of New York, New York, NY, United States.
Trisha DindyalDepartment of Psychology, Queens College, City University of New York, New York, NY, United States.
Vishal VigDepartment of Psychology, Queens College, City University of New York, New York, NY, United States.
Richard J BodnarBehavioral and Cognitive Neuroscience Cluster, Psychology Doctoral Program, The Graduate Center, City University of New York, New York, NY, United States; Department of Psychology, Queens College, City University of New York, New York, NY, United States. Electronic address: richard.bodnar@qc.cuny.edu.
Queens College, CUNY · USThe Graduate Center, CUNY · USCity University of New York · US

Funding

Neuropharmacology of Learned Food PreferencesR01DK071761 · NIDDK · BROOKLYN COLLEGE · PI SCLAFANI, ANTHONY · 2005 to 2009
$1.3M
NIDDK NIH HHS DK071761NIDDK NIH HHS R01 DK071761
6 · The paper itself

Abstract

Systemic dopamine (DA) D1 (SCH23390: SCH) and D2 (raclopride: RAC) antagonists blocked fructose-conditioned flavor preference (CFP) acquisition and expression. Fructose-CFP acquisition was eliminated by medial prefrontal cortex (mPFC) SCH and mPFC or amygdala (AMY) RAC. Fructose-CFP expression was reduced following SCH or RAC in AMY or nucleus accumbens (NAc). The present study examined fructose-CFP acquisition and expression following SCH and RAC in the medial orbital frontal cortex (MOFC), another ventral tegmental area DA target. For fructose-CFP acquisition, five groups of rats received vehicle, SCH (24 or 48 nmol) or RAC (24 or 48 nmol) in the MOFC 0.5h prior to 8 training sessions with one flavor (CS+/Fs) mixed in 8% fructose and 0.2% saccharin, and another flavor (CS-/s) mixed in 0.2% saccharin. In six 2-bottle choice tests in 0.2% saccharin, similar fructose-CFP preferences occurred in groups trained with vehicle (76-77%), SCH24 (69-78%), SCH48 (70-74%) and RAC48 (85-92%). RAC24-trained rats displayed significant CS+ preferences during the first (79%) and third (71%), but not second (58%) test pair. For fructose-CFP expression, rats similarly trained with CS+/Fs and CS- solutions received 2-bottle choice tests following MOFC injections of SCH or RAC (12-48 nmol). CS+ preference expression was significantly reduced by RAC (48 nmol: 58%), but not SCH relative to vehicle (78%). A control group receiving RAC in the dorsolateral prefrontal cortex displayed fructose-CFP expression similar to vehicle. These data demonstrate differential frontal cortical DA mediation of fructose-CFP with mPFC D1 and D2 signaling exclusively mediating acquisition, and MOFC D2 signaling primarily mediating expression.

Indexed as

FructoseSweetening AgentsAnalysis of VarianceAnimalsConditioning, PsychologicalDopamine AgentsDose-Response Relationship, DrugEatingFood PreferencesMalePrefrontal CortexRatsRats, Sprague-DawleyReceptors, DopamineSignal TransductionDopamine AgentsFructoseReceptors, DopamineSweetening AgentsFlavor–flavor learningRacloprideSaccharinSCH23390Sweet taste

Identifiers

PMID25446441
PMCPMC4388031
OpenAlexW2045513104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.