Evidence map›Paper›PMID 25446425›Full record

ArticleJournal of vascular and interventional radiology : JVIR2015

Percutaneous microwave ablation of hepatocellular carcinoma with a gas-cooled system: initial clinical results with 107 tumors.

Timothy J Ziemlewicz, J Louis Hinshaw, Meghan G Lubner, Christopher L Brace, Marci L Alexander, Parul Agarwal, Fred T Lee

Abstract read
In one paragraph

Article in Journal of vascular and interventional radiology : JVIR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Clinical translation of abdominal histotripsy: a review of preclinical studies in large animal models.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. Local treatment of oligometastatic disease: current role.The British journal of radiology · 2019
    Review
  7. Article
  8. Article
  9. Article
  10. Percutaneous microwave ablation for HCV-related hepatocellular carcinoma: Efficacy, safety, and survival.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019
    Article
  11. Review
  12. Treatment of Primary Liver Tumors and Liver Metastases, Part 2: Non-Nuclear Medicine Techniques.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Review
  13. Article
  14. Potential Mechanisms of Vascular Thrombosis after Microwave Ablation in an in Vivo Liver.Journal of vascular and interventional radiology : JVIR · 2017
    Article
  15. Efficient 3-D Reconstruction in Ultrasound Elastography via a Sparse Iteration Based on Markov Random Fields.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017
    Article
  16. Microwave ablation in primary and secondary liver tumours: technical and clinical approaches.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2017
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Timothy J ZiemlewiczDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave., E3/366 CSC, Madison, WI 53792.. Electronic address: tziemlewicz@uwhealth.org.
J Louis HinshawDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave., E3/366 CSC, Madison, WI 53792.
Meghan G LubnerDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave., E3/366 CSC, Madison, WI 53792.
Christopher L BraceDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave., E3/366 CSC, Madison, WI 53792.; Department of Biomedical Engineering, University of Wisconsin-Madison, 600 Highland Ave., E3/366 CSC, Madison, WI 53792.; Department of Medical Physics, University of Wisconsin-Madison, 600 Highland Ave., E3/366 CSC, Madison, WI 53792.
Marci L AlexanderDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave., E3/366 CSC, Madison, WI 53792.
Parul AgarwalSection of Hepatology, Department of Medicine, University of Wisconsin-Madison, 600 Highland Ave., E3/366 CSC, Madison, WI 53792.
Fred T LeeDepartment of Radiology, University of Wisconsin-Madison, 600 Highland Ave., E3/366 CSC, Madison, WI 53792.

Funding

Optimizing microwave ablation techniques for targeted cancer therapyR01CA142737 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI BRACE, CHRISTOPHER L · 2010 to 2013
$1.2M
NCI NIH HHS R01 CA142737
6 · The paper itself

Abstract

purposeTo retrospectively review the results of hepatocellular carcinoma (HCC) treatment with a high-power, gas-cooled, multiantenna-capable microwave device. MATERIALS AND

methodsA total of 107 HCCs in 75 patients (65 men) with a mean age of 61 years (range, 44-82 y) were treated via percutaneous approach. Combination microwave ablation and transarterial chemoembolization was performed for 22 tumors in 19 patients with tumors larger than 4 cm (n = 10), tumors larger than 3 cm with ill-defined margins (n = 7), or lesions not identified with ultrasonography (n = 5). Mean tumor size was 2.1 cm (range, 0.5-4.2 cm), with median follow-up of 14 months, for ablation alone; compared with 3.7 cm (range, 1.0-7.0 cm) and 12 months, respectively, for combination therapy. All procedures were performed with a single microwave system (Certus 140) with one to three 17-gauge antennas.

resultsMean ablation time was 5.3 minutes (range, 1-11.5 min). All treatments were considered technically successful in a single session. Primary technique effectiveness rates were 91.6% (98 of 107) overall, 93.7% (89 of 95) for tumors 4 cm or smaller, and 75.0% (nine of 12) for tumors larger than 4 cm; and 91.8% (78 of 85) for ablation alone and 90.9% (20 of 22) for combination therapy. There was no major complication or procedure-related mortality. The overall survival rate was 76.0% at a median 14-month clinical follow-up, with most deaths related to end-stage liver disease (n = 11) or multifocal HCC (n = 5).

conclusionsTreating HCC with a gas-cooled, multiantenna-capable microwave ablation device is safe, with promising treatment effectiveness.

Indexed as

AdultAgedAged, 80 and overCarcinoma, HepatocellularCatheter AblationChemoembolization, TherapeuticCombined Modality TherapyFemaleFollow-Up StudiesHumansLiverLiver NeoplasmsMagnetic Resonance ImagingMaleMicrowavesMiddle Aged

Identifiers

PMID25446425
PMCPMC5361217

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.