ReviewNature reviews. Genetics2015
Single-cell and multivariate approaches in genetic perturbation screens.
Review in Nature reviews. Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed.
- Critical assessment in the age of AI: challenges and opportunities for computational biology.Bioinformatics advances · 2026Article
- Integrating Biological Knowledge for Robust Microscopy Image Profiling onProceedings. IEEE International Conference on Computer Vision · 2025Article
- Systematic data analysis pipeline for quantitative morphological cell phenotyping.Computational and structural biotechnology journal · 2024Review
- A systematic evaluation of computational methods for cell segmentation.bioRxiv : the preprint server for biology · 2024Article
- A systematic evaluation of computational methods for cell segmentation.Briefings in bioinformatics · 2024Article
- Combining machine learning with high-content imaging to infer ciprofloxacin susceptibility in isolates of Salmonella Typhimurium.Nature communications · 2024Article
- A deep semantic network-based image segmentation of soybean rust pathogens.Frontiers in plant science · 2024Article
- Theory for High-Throughput Genetic Interaction Screening.ACS synthetic biology · 2023Article
- Preparing Planarian Cells for High-Content Fluorescence Microscopy Using RNA in Situ Hybridization and Immunocytochemistry.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Assignment of unimodal probability distribution models for quantitative morphological phenotyping.BMC biology · 2022Article
- Insights Into the Biogenesis and Emerging Functions of Lipid Droplets From Unbiased Molecular Profiling Approaches.Frontiers in cell and developmental biology · 2022Review
- Integrated genome and tissue engineering enables screening of cancer vulnerabilities in physiologically relevant perfusable ex vivo cultures.Biomaterials · 2022Article
- Organoids in image-based phenotypic chemical screens.Experimental & molecular medicine · 2021Review
- From Descriptive to Functional Genomics of Leukemias Focusing on Genome Engineering Techniques.International journal of molecular sciences · 2021Review
- MAPS: machine-assisted phenotype scoring enables rapid functional assessment of genetic variants by high-content microscopy.BMC bioinformatics · 2021Article
- Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures.Nature communications · 2021Article
- Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer.Journal of personalized medicine · 2021Review
- Review
- Single-Cell RNA-Seq of Cisplatin-Treated Adult Stria Vascularis Identifies Cell Type-Specific Regulatory Networks and Novel Therapeutic Gene Targets.Frontiers in molecular neuroscience · 2021Article
- Exploiting Single-Cell Tools in Gene and Cell Therapy.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large-scale genetic perturbation screens are a classical approach in biology and have been crucial for many discoveries. New technologies can now provide unbiased quantification of multiple molecular and phenotypic changes across tens of thousands of individual cells from large numbers of perturbed cell populations simultaneously. In this Review, we describe how these developments have enabled the discovery of new principles of intracellular and intercellular organization, novel interpretations of genetic perturbation effects and the inference of novel functional genetic interactions. These advances now allow more accurate and comprehensive analyses of gene function in cells using genetic perturbation screens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.