Trial reportPhysiology & behavior2015
Oxytocin and vasopressin modulate risk-taking.
Trial report in Physiology & behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats.Behavioral neuroscience · 2025Article
- Neuropeptidergic systems in psychiatric disorders.Frontiers in endocrinology · 2025Review
- The Role of Oxytocin and Vasopressin in People with Borderline Personality Disorder: A Closer Look at Adolescents.International journal of molecular sciences · 2024Review
- The pharmacodynamic modulation effect of oxytocin on resting state functional connectivity network topology.Frontiers in pharmacology · 2024Article
- Intranasal Oxytocin Modulates Decision-Making Depending on Outcome Predictability-A Randomized Within-Subject Controlled Trial in Healthy Males.Biomedicines · 2022Article
- Oxytocin moderates the association between testosterone-cortisol ratio and trustworthiness: A randomized placebo-controlled study.Comprehensive psychoneuroendocrinology · 2021Article
- Influence of HFD-induced precocious puberty on neurodevelopment in mice.Nutrition & metabolism · 2021Article
- Oxytocin-induced anxiogenic behavior in juvenile male rats.Animal cells and systems · 2021Article
- Sexually dimorphic behavioral and neural responses to a predator scent.Behavioural brain research · 2020Article
- Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery.Frontiers in neuroendocrinology · 2018Review
- Differential Effects of Intranasal Vasopressin on the Processing of Adult and Infant Cues: An ERP Study.Frontiers in human neuroscience · 2018Article
- Sex differences in neural activation following different routes of oxytocin administration in awake adult rats.Psychoneuroendocrinology · 2017Article
- The (Null) Effect of Affective Touch on Betrayal Aversion, Altruism, and Risk Taking.Frontiers in behavioral neuroscience · 2017Article
- Relationship between Salivary Oxytocin Levels and Generosity in Preschoolers.Scientific reports · 2016Article
- Age and Social Context Modulate the Effect of Anxiety on Risk-taking in Pediatric Samples.Journal of abnormal child psychology · 2016Article
- The Microbiome and Mental Health: Looking Back, Moving Forward with Lessons from Allergic Diseases.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2016Review
- Neural systems and hormones mediating attraction to infant and child faces.Frontiers in psychology · 2015Review
- Oxytocin modulates meta-mood as a function of age and sex.Frontiers in aging neuroscience · 2015Article
- Hormones as "difference makers" in cognitive and socioemotional aging processes.Frontiers in psychology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The modulation of risk-taking is critical for adaptive and optimal behavior. This study examined how oxytocin (OT) and arginine vasopressin (AVP) influence risk-taking in function of three parameters: sex, risk-valence, and social context. Twenty-nine healthy adults (14 males) completed a risk-taking task, the Stunt task, both in a social-stress (evaluation by unfamiliar peers) and non-social context, in three separate drug treatment sessions. During each session, one of three drugs, OT, AVP, or placebo (PLC), was administered intra-nasally. OT and AVP relative to PLC reduced betting-rate (risk-averse effect). This risk-averse effect was further qualified: AVP reduced risk-taking in the positive risk-valence (high win-probability), and regardless of social context or sex. In contrast, OT reduced risk-taking in the negative risk-valence (low win-probability), and only in the social-stress context and men. The reduction in risk-taking might serve a role in defensive behavior. These findings extend the role of these neuromodulators to behaviors beyond the social realm. How the behavioral modulation of risk-taking maps onto the function of the neural targets of OT and AVP may be the next step in this line of research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.