Evidence map›Paper›PMID 25445767›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2015

Adjusting for patient demographics has minimal effects on rates of adenoma detection in a large, community-based setting.

Christopher D Jensen, Chyke A Doubeni, Virginia P Quinn, Theodore R Levin, Ann G Zauber, Joanne E Schottinger, Amy R Marks, Wei K Zhao, Jeffrey K Lee, Nirupa R Ghai and 4 more

Open access · greenAbstract read
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Observational
  4. Article
  5. Article
  6. Unlocking quality in endoscopic mucosal resection.World journal of gastrointestinal endoscopy · 2023
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. FITting ADR to colonoscopy indication.United European gastroenterology journal · 2017
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Christopher D JensenKaiser Permanente Division of Research, Oakland, California.
Chyke A DoubeniKaiser Permanente Division of Research, Oakland, California.
Virginia P QuinnKaiser Permanente Division of Research, Oakland, California.
Theodore R LevinKaiser Permanente Division of Research, Oakland, California.
Ann G ZauberKaiser Permanente Division of Research, Oakland, California.
Joanne E SchottingerKaiser Permanente Division of Research, Oakland, California.
Amy R MarksKaiser Permanente Division of Research, Oakland, California.
Wei K ZhaoKaiser Permanente Division of Research, Oakland, California.
Jeffrey K LeeKaiser Permanente Division of Research, Oakland, California.
Nirupa R GhaiKaiser Permanente Division of Research, Oakland, California.
Jennifer L SchneiderKaiser Permanente Division of Research, Oakland, California.
Bruce H FiremanKaiser Permanente Division of Research, Oakland, California.
Charles P QuesenberryKaiser Permanente Division of Research, Oakland, California.
Douglas A CorleyKaiser Permanente Division of Research, Oakland, California. Electronic address: Douglas.Corley@kp.org.
Kaiser Permanente · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
CRN4: Cancer Research Resources & Collaboration in Integrated Health Care SystemsU24CA171524 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI KUSHI, LAWRENCE H · 2012 to 2016
$16.0M
Optimizing the use of colonoscopy for CRC screening in a large community-basedU54CA163262 · NCI · KAISER FOUNDATION RESEARCH INSTITUTE · PI CORLEY, DOUGLAS ALLEN, DOUBENI, CHYKE ABADAMA · 2011 to 2017
$9.6M
TRAINING PROGRAM IN DISGESTIVE DISEASES AND NUTRITIONT32DK007007 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AVERIL I MA · 1986 to 2026
$6.4M
NCI NIH HHS P30 CA008748NCI NIH HHS U24 CA171524NCI NIH HHS U54 CA163262NIDDK NIH HHS T32 DK007007NIDDK NIH HHS T32DK007007
6 · The paper itself

Abstract

BACKGROUND &

aimsReliable estimates of adenoma detection rates (ADRs) are needed to inform colonoscopy quality standards, yet little is known about the contributions of patient demographics to variation in ADRs. We evaluated the effects of adjusting for patient age, race/ethnicity, and family history of colorectal cancer on variations in ADRs and the relative rank order of physicians.

methodsIn a retrospective cohort study, we collected data from Kaiser Permanente Northern California members who were ≥ 50 years old who received colonoscopies from 2006 through 2008. We evaluated ADRs (before and after adjustment for age, sex, race/ethnicity, and family history of colorectal cancer) for 102 endoscopists who performed 108,662 total colonoscopies and 20,792 screening colonoscopies. Adenomas were identified from the pathology database, and cancers were detected by using the Kaiser Permanente Northern California cancer registry.

resultsAbout two-thirds of examiners had unadjusted ADRs for screening exams that met gastroenterology society guidelines (>25% for men and >15% for women), although rates of detection varied widely (7.7%-61.5% for male patients and 1.7%-45.6% for female patients). Adjusting for case mix reduced the variation in detection rates (from 8-fold to 3-fold for male patients and from 27-fold to 5-fold for female patients), but the median change in physician order by detection rate was just 2 ranks, and few physicians changed quartiles of detection. For example, only 3 of 102 endoscopists moved into and 3 out of the lowest quartile of ADR.

conclusionsIn a community-based setting, most endoscopists met the ADR standards, although there was wide variation in ADRs, which was similar to that reported from academic and referral settings. Case-mix adjustment reduced variability but had only small effects on differences in ADRs between physicians, and only a small percentage of physicians changed quartiles of detection. Adjustments to ADRs are therefore likely only needed in settings in which physicians have very different patient demographics, such as in sex or age. Moderate differences in patient demographics between physicians are unlikely to substantially change rates of adenoma detection.

Indexed as

Health Services ResearchAdenomaAgedAged, 80 and overAge FactorsCaliforniaCohort StudiesColonoscopyEarly Detection of CancerFemaleGastrointestinal NeoplasmsHumansMaleMiddle AgedRetrospective StudiesSensitivity and SpecificityColon CancerEndoscopyNeoplasmPolyp

Identifiers

PMID25445767
PMCPMC4369190
OpenAlexW1974694940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.