ArticleMathematical biosciences2014
A kinetic model for the frequency dependence of cholinergic modulation at hippocampal GABAergic synapses.
Article in Mathematical biosciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Septohippocampal transmission from parvalbumin-positive neurons features rapid recovery from synaptic depression.Scientific reports · 2021Article
- Effects of Radiofrequency Electromagnetic Radiation on Neurotransmitters in the Brain.Frontiers in public health · 2021Review
- Special Issue from the 2017 International Conference on Mathematical Neuroscience.Journal of mathematical neuroscience · 2019Article
- Model-Based Inference of Synaptic Transmission.Frontiers in synaptic neuroscience · 2019Review
- Effect of Neuromodulation of Short-term Plasticity on Information Processing in Hippocampal Interneuron Synapses.Journal of mathematical neuroscience · 2018Article
- Data Driven Models of Short-Term Synaptic Plasticity.Frontiers in computational neuroscience · 2018Article
- Presynaptic cholinergic neuromodulation alters the temporal dynamics of short-term depression at parvalbumin-positive basket cell synapses from juvenile CA1 mouse hippocampus.Journal of neurophysiology · 2015Article
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3 authors.
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Abstract
In this paper we use a simple model of presynaptic neuromodulation of GABA signaling to decipher paired whole-cell recordings of frequency dependent cholinergic neuromodulation at CA1 parvalbumin-containing basket cell (PV BC)-pyramidal cell synapses. Variance-mean analysis is employed to normalize the data, which is then used to estimate parameters in the mathematical model. Various parameterizations and hidden parameter dependencies are investigated using Markov Chain Monte Carlo (MCMC) parameter estimation techniques. This analysis reveals that frequency dependence of cholinergic modulation requires both calcium-dependent recovery from depression and mAChR-induced inhibition of presynaptic calcium entry. A reduction in calcium entry into the presynaptic terminal in the kinetic model accounted for the frequency-dependent effects of mAChR activation.
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