ReviewAdvanced drug delivery reviews2015
Spatial regulation of controlled bioactive factor delivery for bone tissue engineering.
Review in Advanced drug delivery reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 3D-printed scaffold-based strategies for enthesis regeneration: a systematic review of the literature.Frontiers in bioengineering and biotechnology · 2026Pooled it
- Injectable hydrogels for bone regeneration: from materials design to clinical translation.RSC advances · 2026Review
- Harnessing copper-strontium synergy in an injectable composite for multi-pathway bone regeneration.RSC advances · 2026Article
- Effects of polycaprolactone/hydroxyapatite nanocomposite scaffolds combined with platelet-rich fibrin for repair of rabbit calvarial bone defects.Veterinary research forum : an international quarterly journal · 2026Article
- Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi-System Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A Comprehensive Review of Thermosensitive Hydrogels: Mechanism, Optimization Strategies, and Applications.Gels (Basel, Switzerland) · 2025Review
- Cellulose-Based Scaffolds with Prolonged Dexamethasone Release for Bone Tissue Engineering.Molecules (Basel, Switzerland) · 2025Article
- Advancements in GelMA bioactive hydrogels: Strategies for infection control and bone tissue regeneration.Theranostics · 2025Review
- The Need for Research on the Comparison of Sensory Characteristics between Cultured Meat Produced Using Scaffolds and Meat.Food science of animal resources · 2024Review
- Articular cartilage repair biomaterials: strategies and applications.Materials today. Bio · 2024Review
- Repair of Infected Bone Defects with Hydrogel Materials.Polymers · 2024Review
- Novel scaffold platforms for simultaneous induction osteogenesis and angiogenesis in bone tissue engineering: a cutting-edge approach.Journal of nanobiotechnology · 2023Review
- Development of three-layer collagen scaffolds to spatially direct tissue-specific cell differentiation for enthesis repair.Materials today. Bio · 2023Article
- Article
- Up-to-date progress in bioprinting of bone tissue.International journal of bioprinting · 2023Review
- Engineering Spatiotemporal Control in Vascularized Tissues.Bioengineering (Basel, Switzerland) · 2022Review
- Statistic Copolymers Working as Growth Factor-Binding Mimics of Fibronectin.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Growth Factor Immobilization Strategies for Musculoskeletal Disorders.Current osteoporosis reports · 2022Review
- Synthetic materials in craniofacial regenerative medicine: A comprehensive overview.Frontiers in bioengineering and biotechnology · 2022Review
- Dual drug delivery platforms for bone tissue engineering.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Limitations of current treatment options for critical size bone defects create a significant clinical need for tissue engineered bone strategies. This review describes how control over the spatiotemporal delivery of growth factors, nucleic acids, and drugs and small molecules may aid in recapitulating signals present in bone development and healing, regenerating interfaces of bone with other connective tissues, and enhancing vascularization of tissue engineered bone. State-of-the-art technologies used to create spatially controlled patterns of bioactive factors on the surfaces of materials, to build up 3D materials with patterns of signal presentation within their bulk, and to pattern bioactive factor delivery after scaffold fabrication are presented, highlighting their applications in bone tissue engineering. As these techniques improve in areas such as spatial resolution and speed of patterning, they will continue to grow in value as model systems for understanding cell responses to spatially regulated bioactive factor signal presentation in vitro, and as strategies to investigate the capacity of the defined spatial arrangement of these signals to drive bone regeneration in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.