Evidence map›Paper›PMID 25445717›Full record

ReviewBlood reviews2015

Global characteristics of childhood acute promyelocytic leukemia.

L Zhang, A Samad, M S Pombo-de-Oliveira, G Scelo, M T Smith, J Feusner, J L Wiemels, C Metayer

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Blood reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Arsenic Combined With All-Trans Retinoic Acid for Pediatric Acute Promyelocytic Leukemia: Report From the CCLG-APL2016 Protocol Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021
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  15. Acute Promyelocytic Leukemia in Children: A Single Centre Experience from Turkey.Mediterranean journal of hematology and infectious diseases · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

L ZhangSchool of Public Health, University of California, Berkeley, USA. Electronic address: luoping@berkeley.edu.
A SamadSchool of Public Health, University of California, Berkeley, USA. Electronic address: aaida.samad@gmail.com.
M S Pombo-de-OliveiraPediatric Hematology-Oncology Program, Research Center-National Institute of Cancer, Rio de Janeiro, Brazil. Electronic address: mpombo@inca.gov.br.
G SceloInternational Agency for Research on Cancer (IARC), Lyon, France. Electronic address: scelog@iarc.fr.
M T SmithSchool of Public Health, University of California, Berkeley, USA. Electronic address: martynts@berkeley.edu.
J FeusnerDepartment of Hematology, Children's Hospital and Research Center Oakland, Oakland, USA. Electronic address: jfeusner@mail.cho.org.
J L WiemelsDepartment of Epidemiology and Biostatistics, University of California, San Francisco, USA. Electronic address: joe.wiemels@ucsf.edu.
C MetayerSchool of Public Health, University of California, Berkeley, USA. Electronic address: cmetayer@berkeley.edu.

Funding

Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, MARTYN T · 1987 to 2025
$74.6M
Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1M
Project 3: Prenatal Exposure, DNA Methylation & Childhood LeukemiaP01ES018172 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2009 to 2013
$3.7M
NIEHS NIH HHS P01 ES018172NIEHS NIH HHS P01ES018172NIEHS NIH HHS P42 ES004705NIEHS NIH HHS P42ES04705NIEHS NIH HHS R01 ES009137NIEHS NIH HHS R01ES009137World Health Organization 001
6 · The paper itself

Abstract

Acute promyelocytic leukemia (APL) comprises approximately 5-10% of childhood acute myeloid leukemia (AML) cases in the US. While variation in this percentage among other populations was noted previously, global patterns of childhood APL have not been thoroughly characterized. In this comprehensive review of childhood APL, we examined its geographic pattern and the potential contribution of environmental factors to observed variation. In 142 studies (spanning >60 countries) identified, variation was apparent-de novo APL represented from 2% (Switzerland) to >50% (Nicaragua) of childhood AML in different geographic regions. Because a limited number of previous studies addressed specific environmental exposures that potentially underlie childhood APL development, we gathered 28 childhood cases of therapy-related APL, which exemplified associations between prior exposures to chemotherapeutic drugs/radiation and APL diagnosis. Future population-based studies examining childhood APL patterns and the potential association with specific environmental exposures and other risk factors are needed.

Indexed as

ChildCytogeneticsEnvironmental ExposureGeography, MedicalHumansLeukemia, Promyelocytic, AcutePrognosisRisk FactorsAcute promyelocytic leukemiaAML-M3Environmental exposurePediatric leukemiaRisk factorsTherapy-related leukemia

Identifiers

PMID25445717
PMCPMC4379131

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.