Evidence map›Paper›PMID 25445634›Full record

Trial reportNitric oxide : biology and chemistry2015

Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients.

Michael J Berry, Nicholas W Justus, Jordan I Hauser, Ashlee H Case, Christine C Helms, Swati Basu, Zachary Rogers, Marc T Lewis, Gary D Miller

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nitric oxide : biology and chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03371966 (The Effects of Chronic Dietary Nitrate Supplementation on Constant Work Rate Exercise in High Functioning Middle Aged and Older Adults), which is not on this map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
43.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03371966 nacompletednot on this mapstarted 2017, after this paper: background citation

The Effects of Chronic Dietary Nitrate Supplementation on Constant Work Rate Exercise in High Functioning Middle Aged and Older Adults

TypeinterventionalSponsorWake Forest UniversityRan2017 to 2019Enrolled29ConditionsAgingArmsHigh Nitrate Beetroot Juice, Low Nitrate Beetroot Juice
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Michael J BerryHealth and Exercise Science Department, Wake Forest University, Winston-Salem, NC 27109, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27109, USA. Electronic address: berry@wfu.edu.
Nicholas W JustusHealth and Exercise Science Department, Wake Forest University, Winston-Salem, NC 27109, USA.
Jordan I HauserHealth and Exercise Science Department, Wake Forest University, Winston-Salem, NC 27109, USA.
Ashlee H CaseHealth and Exercise Science Department, Wake Forest University, Winston-Salem, NC 27109, USA.
Christine C HelmsPhysics Department, Wake Forest University, Winston-Salem, NC 27109, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27109, USA.
Swati BasuPhysics Department, Wake Forest University, Winston-Salem, NC 27109, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27109, USA.
Zachary RogersHealth and Exercise Science Department, Wake Forest University, Winston-Salem, NC 27109, USA.
Marc T LewisHealth and Exercise Science Department, Wake Forest University, Winston-Salem, NC 27109, USA.
Gary D MillerHealth and Exercise Science Department, Wake Forest University, Winston-Salem, NC 27109, USA; Translational Science Center, Wake Forest University, Winston-Salem, NC 27109, USA.
Wake Forest University · US

Funding

Standardized Rehabilitation for ICU Patients with Acute Respiratory FailureR01NR011186 · NINR · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MORRIS, PETER E · 2009 to 2013
$2.6M
NINR NIH HHS NR011186NINR NIH HHS R01 NR011186
6 · The paper itself

Abstract

Dietary nitrate (NO3(-)) supplementation via beetroot juice has been shown to increase the exercise capacity of younger and older adults. The purpose of this study was to investigate the effects of acute NO3(-) ingestion on the submaximal constant work rate exercise capacity of COPD patients. Fifteen patients were assigned in a randomized, single-blind, crossover design to receive one of two treatments (beetroot juice then placebo or placebo then beetroot juice). Submaximal constant work rate exercise time at 75% of the patient's maximal work capacity was the primary outcome. Secondary outcomes included plasma NO3(-) and nitrite (NO2(-)) levels, blood pressure, heart rate, oxygen consumption (VO2), dynamic hyperinflation, dyspnea and leg discomfort. Relative to placebo, beetroot ingestion increased plasma NO3(-) by 938% and NO2(-) by 379%. Median (+interquartile range) exercise time was significantly longer (p = 0.031) following the ingestion of beetroot versus placebo (375.0 + 257.0 vs. 346.2 + 148.0 s, respectively). Compared with placebo, beetroot ingestion significantly reduced iso-time (p = 0.001) and end exercise (p = 0.008) diastolic blood pressures by 6.4 and 5.6 mmHg, respectively. Resting systolic blood pressure was significantly reduced (p = 0.019) by 8.2 mmHg for the beetroot versus the placebo trial. No other variables were significantly different between the beetroot and placebo trials. These results indicate that acute dietary NO3(-) supplementation can elevate plasma NO3(-) and NO2(-) concentrations, improve exercise performance, and reduce blood pressure in COPD patients.

Indexed as

AgedBeta vulgarisBeveragesBlood PressureDietary SupplementsDyspneaExerciseFemaleHeart RateHumansMaleMiddle AgedNitratesNitritesOxygenPulmonary Disease, Chronic ObstructiveNitratesNitritesOxygenBlood pressureChronic obstructive pulmonary diseaseExerciseNitrateNitric oxideNitrite

Identifiers

PMID25445634
PMCPMC4411191
OpenAlexW2082804715

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.