ArticleMathematical biosciences2015
Circadian characteristics of permissive and suppressive effects of cortisol and their role in homeostasis and the acute inflammatory response.
Article in Mathematical biosciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- A Prospective Cohort Study on the Effects of Repeated Acute Stress on Cortisol Awakening Response and Immune Function in Military Medical Students.Biomedicines · 2024Article
- The influence of light and heavy training weeks on the cortisol and testosterone awakening responses of elite male judokas: is skeletal muscle damage a mediating factor?Biology of sport · 2024Article
- The Physiological and Pharmacological Significance of the Circadian Timing of the HPA Axis: A Mathematical Modeling Approach.Journal of pharmaceutical sciences · 2024Review
- Mathematical modeling of temperature-induced circadian rhythms.Frontiers in systems biology · 2024Article
- Unraveling biomarkers of exposure for tenuazonic acid through urinary metabolomics.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2023Article
- Circadian rhythms and the HPA axis: A systems view.WIREs mechanisms of disease · 2021Review
- Mathematical modeling of mammalian circadian clocks affecting drug and disease responses.Journal of pharmacokinetics and pharmacodynamics · 2021Review
- Dynamical modeling of pro- and anti-inflammatory cytokines in the early stage of septic shock.In silico biology · 2020Article
- Mathematical modeling informs the impact of changes in circadian rhythms and meal patterns on insulin secretion.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- A Circadian Rhythm in both Complement Cascade (ComC) Activation and Sphingosine-1-Phosphate (S1P) Levels in Human Peripheral Blood Supports a Role for the ComC-S1P Axis in Circadian Changes in the Number of Stem Cells Circulating in Peripheral Blood.Stem cell reviews and reports · 2018Article
- Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis: the intertwining entraining roles of light and feeding.American journal of physiology. Endocrinology and metabolism · 2018Article
- Sleep disorders and health-related quality of life in patients with interstitial lung disease.Sleep & breathing = Schlaf & Atmung · 2018Article
- Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat.PloS one · 2018Article
- Daily variation of gene expression in diverse rat tissues.PloS one · 2018Article
- On the analysis of complex biological supply chains: From Process Systems Engineering to Quantitative Systems Pharmacology.Computers & chemical engineering · 2017Article
- Understanding Physiology in the Continuum: Integration of Information from Multiple -Frontiers in pharmacology · 2017Article
- Altered Neuroendocrine Immune Responses, a Two-Sword Weapon against Traumatic Inflammation.International journal of biological sciences · 2017Review
- The Synergistic Role of Light-Feeding Phase Relations on Entraining Robust Circadian Rhythms in the Periphery.Gene regulation and systems biology · 2017Article
- The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity.Physiological genomics · 2016Article
- Physiologically-based pharmacokinetic models: approaches for enabling personalized medicine.Journal of pharmacokinetics and pharmacodynamics · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In this work we explore a semi-mechanistic model that considers cortisol's permissive and suppressive effects through the regulation of cytokine receptors and cytokines respectively. Our model reveals the proactive role of cortisol during the resting period and its reactive character during the body's activity phase. Administration of an acute LPS dose during the night, when cortisol's permissive effects are higher than suppressive, leads to increased cytokine levels compared to LPS administration at morning when cortisol's suppressive effects are higher. Interestingly, our model presents a hysteretic behavior where the relative predominance of permissive or suppressive effects results not only from cortisol levels but also from the previous states of the model. Therefore, for the same cortisol levels, administration of an inflammatory stimulus at cortisol's ascending phase, that follows a time period where cytokine receptor expression is elevated ultimately sensitizing the body for the impending stimulus, leads to higher cytokine expression compared to administration of the same stimulus at cortisol's descending phase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.