ArticleFungal genetics and biology : FG & B2015
Cryptococcus neoformans Yap1 is required for normal fluconazole and oxidative stress resistance.
Article in Fungal genetics and biology : FG & B, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Recurrent mutations in the stress regulator Cap1 reveal a trade-off between azole resistance and oxidative stress response in Candida albicans.PLoS biology · 2026Article
- A Quick reCAP: DiscoveringJournal of fungi (Basel, Switzerland) · 2024Article
- Combating increased antifungal drug resistance inActa biochimica et biophysica Sinica · 2023Review
- Oxidative stress response pathways in fungi.Cellular and molecular life sciences : CMLS · 2022Review
- The bZIP Ap1 transcription factor is a negative regulator of virulence attributes of the anthropophilic dermatophyteCurrent research in microbial sciences · 2022Article
- The NADPH Oxidase A ofJournal of fungi (Basel, Switzerland) · 2021Article
- Regulatory Mechanism of the Atypical AP-1-Like Transcription Factor Yap1 in Cryptococcus neoformans.mSphere · 2019Article
- Yeast AP-1 like transcription factors (Yap) and stress response: a current overview.Microbial cell (Graz, Austria) · 2019Review
- Contributions ofAntimicrobial agents and chemotherapy · 2018Article
- Thioredoxin and Glutaredoxin Systems Required for Oxidative Stress Resistance, Fungicide Sensitivity, and Virulence of Alternaria alternata.Applied and environmental microbiology · 2018Article
- Host-Pathogen Interactions Mediated by MDR Transporters in Fungi: As Pleiotropic as it Gets!Genes · 2018Review
- Roles of Three Cryptococcus neoformans and Cryptococcus gattii Efflux Pump-Coding Genes in Response to Drug Treatment.Antimicrobial agents and chemotherapy · 2018Article
- Integrated transcriptomic analysis of Trichosporon Asahii uncovers the core genes and pathways of fluconazole resistance.Scientific reports · 2017Article
- Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus.Antimicrobial agents and chemotherapy · 2017Article
- Stress Adaptation.Microbiology spectrum · 2017Review
- A novel bZIP protein, Gsb1, is required for oxidative stress response, mating, and virulence in the human pathogen Cryptococcus neoformans.Scientific reports · 2017Article
- A Population Genomics Approach to Assessing the Genetic Basis of Within-Host Microevolution Underlying Recurrent Cryptococcal Meningitis Infection.G3 (Bethesda, Md.) · 2017Article
- Aspergillus fumigatus virulence through the lens of transcription factors.Medical mycology · 2017Review
- Transcriptomic responses of the basidiomycete yeast Sporobolomyces sp. to the mycotoxin patulin.BMC genomics · 2016Article
- Anti-Immune Strategies of Pathogenic Fungi.Frontiers in cellular and infection microbiology · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Cryptococcus neoformans is a pathogen that is the most common cause of fungal meningitis. As with most fungal pathogens, the most prevalent clinical antifungal used to treat Cryptococcosis is orally administered fluconazole. Resistance to this antifungal is an increasing concern in treatment of fungal disease in general. Our knowledge of the specific determinants involved in fluconazole resistance in Cryptococcus is limited. Here we report the identification of an important genetic determinant of fluconazole resistance in C. neoformans that encodes a basic region-leucine zipper transcription factor homologous to Saccharomyces cerevisiae Yap1. Expression of a codon-optimized form of the Cn YAP1 cDNA in S. cerevisiae complemented defects caused by loss of the endogenous S. cerevisiae YAP1 gene and activated transcription from a reporter gene construct. Mutant strains of C. neoformans lacking YAP1 were hypersensitive to a range of oxidative stress agents but importantly also to fluconazole. Loss of Yap1 homologues from other fungal pathogens like Candida albicans or Aspergillus fumigatus was previously found to cause oxidant hypersensitivity but had no detectable effect on fluconazole resistance. Our data provide evidence for a unique biological role of Yap1 in wild-type fluconazole resistance in C. neoformans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.