ArticleEuropean journal of heart failure2015
Left ventricular mechanical function: clinical correlates, heritability, and association with parental heart failure.
Article in European journal of heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- The Association of Protein Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction.Circulation. Heart failure · 2023Article
- Left Ventricular Systolic Function Has Strong Independent Genetic Background from Diastolic Function: A Classical Twin Study.Medicina (Kaunas, Lithuania) · 2021Article
- Prognostic Significance of Echocardiographic Measures of Cardiac Remodeling in the Community.Current cardiology reports · 2021Review
- Circulating growth factors and cardiac remodeling in the community: The Framingham Heart Study.International journal of cardiology · 2021Article
- Galectin-3 Inhibition With Modified Citrus Pectin in Hypertension.JACC. Basic to translational science · 2021Article
- The association of non-alcoholic fatty liver disease and cardiac structure and function-Framingham Heart Study.Liver international : official journal of the International Association for the Study of the Liver · 2020Article
- Pathophysiology of Hypertensive Heart Disease: Beyond Left Ventricular Hypertrophy.Current hypertension reports · 2020Review
- Clinical correlates and heritability of cardiac mechanics: The HyperGEN study.International journal of cardiology · 2019Article
- Genetically determined pattern of left ventricular function in normal and hypertensive hearts.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Cardiometabolic Traits and Systolic Mechanics in the Community.Circulation. Heart failure · 2017Article
- Noninvasive Measures of Ventricular-Arterial Coupling and Circumferential Strain Predict Cancer Therapeutics-Related Cardiac Dysfunction.JACC. Cardiovascular imaging · 2016Article
- Heart Failure in Women--Insights from the Framingham Heart Study.Cardiovascular drugs and therapy · 2015Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
aimsNon-invasive measures of cardiac mechanical function may have the potential to serve as markers of risk for heart failure; however, limited data exist regarding clinical correlates and heritability of these measures in the community. METHODS AND
resultsWe used speckle-tracking echocardiography to assess LV strain and synchrony in the Framingham Offspring Study (n = 2816; mean age 67 years, 54% women). In multivariable regression analyses, male gender (vs. female, P < 0.001), higher heart rate (P < 0.0001), and presence of cardiovascular disease (P < 0.001) were associated with worse global peak strains across all planes analysed (longitudinal, transverse, circumferential, and radial). Higher diastolic blood pressure and diabetes were associated with worse longitudinal strain (P < 0.01), and greater body mass index was associated with worse radial strain (P = 0.0004). Overall, however, clinical correlates accounted for only 4-19% of the variation in measures of LV mechanical function. Select measures of LV strain were heritable: longitudinal strain (h(2) = 16%, P = 0.002), transverse strain (h(2) = 15%, P = 0.006), and circumferential strain (h(2) = 30%, P < 0.0001). Furthermore, in a subset of 1437 participants with parental data available, parental heart failure was associated with worse circumferential strain in the offspring free of heart failure (P = 0.01).
conclusionsOur investigation in a large community-based sample identified heritablity and clinical correlates of LV mechanical function, and highlighted an association of parental heart failure with worse global circumferential strain in offspring.
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