ArticleJournal of neuroscience methods2015
Towards real-time detection of seizures in awake rats with GPU-accelerated diffuse optical tomography.
Article in Journal of neuroscience methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 18 citations in OpenAlex.
- Toward real-time diffuse optical tomography: accelerating light propagation modeling employing parallel computing on GPU and CPU.Journal of biomedical optics · 2017Article
- Planar implantable sensor for in vivo measurement of cellular oxygen metabolism in brain tissue.Journal of neuroscience methods · 2017Article
- Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data.Neurophotonics · 2017Article
- Wearable 3-D Photoacoustic Tomography for Functional Brain Imaging in Behaving Rats.Scientific reports · 2016Article
- Evaluating real-time image reconstruction in diffuse optical tomography using physiologically realistic test data.Biomedical optics express · 2015Article
- Noninvasive high-speed photoacoustic tomography of cerebral hemodynamics in awake-moving rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAdvancement in clinically relevant studies like seizure interruption using functional neuro imaging tools has shown that specific changes in hemodynamics precede and accompany seizure onset and propagation. However, preclinical seizure experiments need to be conducted in awake animals with images reconstructed and displayed in real-time.
methodsThis article describes an approach that can be utilized to tackle these challenges. A subject specific head interface and restraining method was designed to allow for DOT to imaging of hemodynamic changes in unanesthetized rats during evoked acute seizures. Using CUDA programming model, the finite-element based nonlinear iterative algorithm for image reconstruction was parallelized.
resultsEarly hemodynamic changes were monitored in real time and observed tens of seconds prior to seizure onset. Utilizing the massive parallelization offered by graphic processing units (GPU), DOT was extended to online image reconstruction within 1s. COMPARISON WITH EXISTING
methodsPre-seizure state related hemodynamic changes were detected in awake rats. 3D monitoring of hemodynamic changes was performed in real time with our parallelized image reconstruction procedure.
conclusionDiffuse optical tomography (DOT) is a promising neuroimaging tool for the investigation of seizures in awake animals.
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