ArticleEpilepsy research2014
Passive fMRI mapping of language function for pediatric epilepsy surgical planning: validation using Wada, ECS, and FMAER.
Article in Epilepsy research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Pediatric Epilepsy Surgery: The Noninvasive Presurgical Evaluation.Pediatric neurosurgery · 2026Review
- Multimodal Imaging in Epilepsy Surgery for Personalized Neurosurgical Planning.Journal of personalized medicine · 2025Review
- Language Lateralization by Passive Auditory fMRI in Presurgical Assessment for Temporal Lobe Epilepsy: A Single-Center Retrospective Study.Journal of clinical medicine · 2024Article
- Consensus on pediatric epilepsy surgery for young children: an investigation by the China Association Against Epilepsy task force on epilepsy surgery.Acta epileptologica · 2023Article
- Discrepant expressive language lateralization in children and adolescents with epilepsy.Annals of clinical and translational neurology · 2022Article
- Clinical Speech fMRI in Children and Adolescents : Development of an Optimal Protocol and Analysis Algorithm.Clinical neuroradiology · 2022Article
- A New Functional Magnetic Resonance Imaging Localizer for Preoperative Language Mapping Using a Sentence Completion Task: Validity, Choice of Baseline Condition, and Test-Retest Reliability.Frontiers in human neuroscience · 2022Article
- Feasibility, Contrast Sensitivity and Network Specificity of Language fMRI in Presurgical Evaluation for Epilepsy and Brain Tumor Surgery.Brain topography · 2021Article
- Presurgical Language fMRI in Children, Adolescents and Young Adults : A Validation Study.Clinical neuroradiology · 2020Article
- Real-time presurgical resting-state fMRI in patients with brain tumors: Quality control and comparison with task-fMRI and intraoperative mapping.Human brain mapping · 2020Article
- Functional MRI and direct cortical stimulation: Prediction of postoperative language decline.Epilepsia · 2019Article
- Electrical Stimulation Mapping of the Brain: Basic Principles and Emerging Alternatives.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2018Article
- Advances in neurocognitive rehabilitation research from 1992 to 2017: The ascension of neural plasticity.Neuropsychology · 2017Review
- Language functional MRI and direct cortical stimulation in epilepsy preoperative planning.Annals of neurology · 2017Article
- Advanced MR imaging in hemispheric low-grade gliomas before surgery; the indications and limits in the pediatric age.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Electrocorticographic mapping of expressive language function without requiring the patient to speak: A report of three cases.Epilepsy & behavior case reports · 2016Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
In this study we validate passive language fMRI protocols designed for clinical application in pediatric epilepsy surgical planning as they do not require overt participation from patients. We introduced a set of quality checks that assess reliability of noninvasive fMRI mappings utilized for clinical purposes. We initially compared two fMRI language mapping paradigms, one active in nature (requiring participation from the patient) and the other passive in nature (requiring no participation from the patient). Group-level analysis in a healthy control cohort demonstrated similar activation of the putative language centers of the brain in the inferior frontal (IFG) and temporoparietal (TPG) regions. Additionally, we showed that passive language fMRI produced more left-lateralized activation in TPG (LI=+0.45) compared to the active task; with similarly robust left-lateralized IFG (LI=+0.24) activations using the passive task. We validated our recommended fMRI mapping protocols in a cohort of 15 pediatric epilepsy patients by direct comparison against the invasive clinical gold-standards. We found that language-specific TPG activation by fMRI agreed to within 9.2mm to subdural localizations by invasive functional mapping in the same patients, and language dominance by fMRI agreed with Wada test results at 80% congruency in TPG and 73% congruency in IFG. Lastly, we tested the recommended passive language fMRI protocols in a cohort of very young patients and confirmed reliable language-specific activation patterns in that challenging cohort. We concluded that language activation maps can be reliably achieved using the passive language fMRI protocols we proposed even in very young (average 7.5 years old) or sedated pediatric epilepsy patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.