ArticleProgress in neuro-psychopharmacology & biological psychiatry2015
Behavioral alterations in rat offspring following maternal immune activation and ELR-CXC chemokine receptor antagonism during pregnancy: implications for neurodevelopmental psychiatric disorders.
Article in Progress in neuro-psychopharmacology & biological psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Ventral and Intermediate Hippocampus Are Required for Object-in-Place Recognition Memory in Mice.eNeuro · 2026Article
- Poly (I:C)-induced maternal immune activation generates impairment of reversal learning performance in offspring.Journal of neurochemistry · 2025Article
- Age-related changes in behavior profile in male offspring of rats treated with poly I:C-induced maternal immune activation in early gestation.Animal models and experimental medicine · 2024Article
- Maternal immune suppression during pregnancy does not prevent abnormal behavior in offspring.Biology of sex differences · 2024Article
- Characterization of cannabinoid plasma concentration, maternal health, and cytokine levels in a rat model of prenatal Cannabis smoke exposure.Scientific reports · 2023Article
- Repeated Exposure to High-THCeNeuro · 2023Article
- Maternal Immune Activation Induces Adolescent Cognitive Deficits Preceded by Developmental Perturbations in Cortical Reelin Signalling.Biomolecules · 2023Article
- Aberrant Phase Precession of Lateral Septal Cells in a Maternal Immune Activation Model of Schizophrenia Risk May Disrupt the Integration of Location with Reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Maternal immune activation as a risk factor for psychiatric illness in the context of the SARS-CoV-2 pandemic.Brain, behavior, & immunity - health · 2021Article
- In utero immune programming of autism spectrum disorder (ASD).Human immunology · 2021Article
- Antipsychotic potential of the type 1 cannabinoid receptor positive allosteric modulator GAT211: preclinical in vitro and in vivo studies.Psychopharmacology · 2021Article
- Sequential perturbations to mouse corticogenesis following in utero maternal immune activation.eLife · 2021Article
- Autism spectrum disorder and severe social impairment associated with elevated plasma interleukin-8.Pediatric research · 2021Article
- Disorganization of Oscillatory Activity in Animal Models of Schizophrenia.Frontiers in neural circuits · 2021Review
- Sensory filtering disruption caused by poly I:C - Timing of exposure and other experimental considerations.Brain, behavior, & immunity - health · 2020Article
- Brain changes in a maternal immune activation model of neurodevelopmental brain disorders.Progress in neurobiology · 2019Review
- Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Variability in PolyIC induced immune response: Implications for preclinical maternal immune activation models.Journal of neuroimmunology · 2018Article
- T-type calcium channels in the orbitofrontal cortex mediate sensory integration as measured using a spontaneous oddity task in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Evolution of structural abnormalities in the rat brain following in utero exposure to maternal immune activation: A longitudinal in vivo MRI study.Brain, behavior, and immunity · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Research suggests that maternal immune activation (MIA) during pregnancy increases the risk of neurodevelopmental disorders including schizophrenia and autism in the offspring. Current theories suggest that inflammatory mediators including cytokines and chemokines may underlie the increased risk of these disorders in humans. For example, elevated maternal interleukin-8 (IL-8) during pregnancy is associated with increased risk of schizophrenia in the offspring. Given this association, the present experiments examined ELR-CXC chemokines CXCL1 and CXCL2, rodent homologues of human IL-8, and activation of their receptors (CXCR1 and CXCR2) in an established rodent model of MIA. Pregnant Long Evans rats were treated with the viral mimetic polyinosinic-polycytidylic acid (polyI:C; 4 mg/kg, i.v.) on gestational day 15. Protein analysis using multiplex assays and ELISA showed that polyI:C significantly increased maternal serum concentrations of interleukin-1β, tumor necrosis factor, and CXCL1 3h after administration. Subsequent experiments tested the role of elevated maternal CXCL1 on behavior of the offspring by administering a CXCR1/CXCR2 antagonist (G31P; 500 μg/kg, i.p.; 1h before, 48 and 96 h after polyI:C treatment). The male offspring of dams treated with polyI:C demonstrated subtle impairments in prepulse inhibition (PPI), impaired associative and crossmodal recognition memory, and altered behavioral flexibility in an operant test battery. While G31P did not completely reverse the behavioral impairments caused by polyI:C, it enhanced PPI during adolescence and strategy set-shifting and reversal learning during young adulthood. These results suggest that while polyI:C treatment significantly increases maternal CXCL1, elevations of this chemokine are not solely responsible for the effects of polyI:C on the behavior of the offspring.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.