Evidence map›Paper›PMID 25444890›Full record

ArticleAnnals of epidemiology2014

Blood spot-based measures of glucose homeostasis and diabetes prevalence in a nationally representative population of young US adults.

Quynh C Nguyen, Eric A Whitsel, Joyce W Tabor, Carmen C Cuthbertson, Mark H Wener, Alan J Potter, Carolyn T Halpern, Ley A Killeya-Jones, Jon M Hussey, Chirayath Suchindran and 1 more

Abstract read
In one paragraph

Article in Annals of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Dried Blood Spots to Assess Cardiovascular-Kidney-Metabolic Health.Journal of the American Heart Association · 2025
    Pooled it
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  8. Data Resource Profile: Add Health Mortality Outcomes Surveillance.International journal of epidemiology · 2024
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  12. Life-course trajectories of body mass index from adolescence to old age: Racial and educational disparities.Proceedings of the National Academy of Sciences of the United States of America · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Quynh C NguyenDepartment of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC. Electronic address: quynh.nguyen@health.utah.edu.
Eric A WhitselDepartment of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Joyce W TaborCarolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Carmen C CuthbertsonDepartment of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Mark H WenerDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA.
Alan J PotterDepartment of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA.
Carolyn T HalpernCarolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Maternal and Child Health, UNC Gillings School of Global Public Health, Chapel Hill, NC.
Ley A Killeya-JonesCarolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Jon M HusseyCarolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Maternal and Child Health, UNC Gillings School of Global Public Health, Chapel Hill, NC.
Chirayath SuchindranDepartment of Biostatistics, UNC Gillings School of Global Public Health, Chapel Hill, NC.
Kathleen Mullan HarrisCarolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Public Policy, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Funding

Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1M
Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
NICHD NIH HHS P01 HD031921NICHD NIH HHS P01-HD31921NICHD NIH HHS P2C HD050924NICHD NIH HHS R24 HD050924
6 · The paper itself

Abstract

purposeWe investigated understudied biomarker-based diabetes among young US adults, traditionally characterized by low cardiovascular disease risk.

methodsWe examined 15,701 participants aged 24 to 32 years at Wave IV of the National Longitudinal Study of Adolescent Health (Add Health, 2008). The study used innovative and relatively noninvasive methods to collect capillary whole blood via finger prick at in-home examinations in all 50 states.

resultsAssays of dried blood spots produced reliable and accurate values of HbA1c. Reliability was lower for fasting glucose and lowest for random glucose. Mean (SD) HbA1c was 5.6% (0.8%). More than a quarter (27.4%) had HbA1c-defined prediabetes. HbA1c was highest in the black, non-Hispanic race/ethnic group, inversely associated with education, and more common among the overweight/obese and physically inactive. The prevalence of diabetes defined by previous diagnosis or use of antidiabetic medication was 2.9%. Further incorporating HbA1c and glucose values, the prevalence increased to 6.8%, and among these participants, 38.9% had a previous diagnosis of diabetes (i.e., aware). Among those aware, 37.6% were treated and 64.0% were controlled (i.e., HbA1c < 7%).

conclusionsA contemporary cohort of young adults faces a historically high risk of diabetes but there is ample opportunity for early detection and intervention.

Indexed as

HomeostasisAdultBlack or African AmericanBlack PeopleBlood GlucoseBody Mass IndexDiabetes Mellitus, Type 2Dried Blood Spot TestingFemaleGlycated HemoglobinHumansLongitudinal StudiesMaleNutrition SurveysPrevalenceReproducibility of ResultsBlood GlucoseGlycated HemoglobinDiabetes mellitusDried blood spot testingGlucoseHbA1cHealth surveysYoung adult

Identifiers

PMID25444890
PMCPMC4255475

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.