ReviewJournal of optometry
Corneal Regeneration After Photorefractive Keratectomy: A Review.
Review in Journal of optometry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06854393 (Lacripep, a Novel Investigational Agent, for Corneal Wound Healing and Ocular Surface Homeostasis), which is not on this map. Cited by 60 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Lacripep, a Novel Investigational Agent, for Corneal Wound Healing and Ocular Surface Homeostasis
Who cites it
60 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Photorefractive keratectomy in patients with thin corneas: systematic review and meta-analysis of clinical outcomes and complications.Journal of cataract and refractive surgery · 2026Pooled it
- Efficacy of single-step transepithelial photorefractive keratectomy in myopia, hyperopia and astigmatism-a systematic review.BMC ophthalmology · 2025Pooled it
- Mitomycin C application after photorefractive keratectomy in high, moderate, or low myopia: Systematic review and meta-analysis.Indian journal of ophthalmology · 2021Pooled it
- Corneal biomechanical properties after SMILE versus FLEX, LASIK, LASEK, or PRK: a systematic review and meta-analysis.BMC ophthalmology · 2019Pooled it
- Comparison of asymmetric and symmetric offset ablation in myopic astigmatism patients.Scientific reports · 2025Trial
- Extensive recurrent pterygium following photorefractive keratectomy: a case report.BMC ophthalmology · 2026Article
- [Excimer laser-assisted penetrating keratoplasty for stromal scarring after epikeratoplasty].Die Ophthalmologie · 2026Article
- Changes in corneal epithelial remodeling and associated factors in highly myopic patients after FS-LASIK.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Amniotic Membrane in Excimer Laser Surface Ablation (ELSA): Mechanisms for Haze Prevention and Broader Ocular Surface Optimisation.Ophthalmology and therapy · 2026Review
- Clinical features of patients who needed more than one-time photorefractive keratectomy (PRK), a retrospective cohort study.BMC ophthalmology · 2025Article
- Temporal Analysis of Tear Fluid Proteome Reveals Critical Corneal Repair Events After Photorefractive Surgery.Investigative ophthalmology & visual science · 2025Article
- Cross-Linked Carboxymethyl Cellulose and Silk Proteins in Corneal Re-Epithelialization: A Case Series.Journal of clinical medicine · 2025Article
- A Narrative Review of Amniotic Membrane Transplantation in Ocular Surface Repair: Unveiling the Immunoregulatory Pathways for Timely Intervention.Ophthalmology and therapy · 2025Review
- Transepithelial Versus Conventional PRK: A Randomized Controlled Study.Ophthalmology and therapy · 2025Article
- In vivo Confocal Microscopy for Corneal and Ocular Surface Pathologies: A Comprehensive Review.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- 8-to-10-Year Follow-Up Results of Photorefractive Keratectomy and Risk Factors for Myopia Regression (Including Near Work Activity) in Southeast Iran.Beyoglu eye journal · 2025Article
- Effects of Lotrafilcon A and Senofilcon A Bandage Contact Lenses on Visual Outcome and Ocular Comfort After Photorefractive Keratectomy.Turkish journal of ophthalmology · 2024Article
- Postoperative Pain Comparison Between Alcohol-Assisted and Transepithelial Photorefractive Keratectomy Using Nepafenac Treatment: A Novel Study.Ophthalmology and therapy · 2024Article
- Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photorefractive keratectomy (PRK) remodels corneal stroma to compensate refractive errors. The removal of epithelium and the ablation of stroma provoke the disruption of corneal nerves and a release of several peptides from tears, epithelium, stroma and nerves. A myriad of cytokines, growth factors, and matrix metalloproteases participate in the process of corneal wound healing. Their balance will determine if reepithelization and stromal remodeling are appropriate. The final aim is to achieve corneal transparency for restoring corneal function, and a proper visual quality. Therefore, wound-healing response is critical for a successful refractive surgery. Our goal is to provide an overview into how corneal wounding develops following PRK. We will also review the influence of intraoperative application of mitomycin C, bandage contact lenses, anti-inflammatory and other drugs in preventing corneal haze and post-PRK pain.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.