Evidence map›Paper›PMID 25444601›Full record

ArticleNeurobiology of aging2015

Does MRI scan acceleration affect power to track brain change?

Christopher R K Ching, Xue Hua, Derrek P Hibar, Chadwick P Ward, Jeffrey L Gunter, Matt A Bernstein, Clifford R Jack, Michael W Weiner, Paul M Thompson, Alzheimer's Disease Neuroimaging Initiative

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Overview of ADNI MRI.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Christopher R K ChingDepartment of Neurology, Neuroscience Graduate Program, UCLA School of Medicine, Los Angeles, CA, USA; Department of Neurology, Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA.
Xue HuaDepartment of Neurology, Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA.
Derrek P HibarDepartment of Neurology, Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA.
Chadwick P WardDepartment of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
Jeffrey L GunterDepartment of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
Matt A BernsteinDepartment of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
Clifford R JackDepartment of Neurology, Mayo Clinic and Foundation, Rochester, MN, USA.
Michael W WeinerDepartment of Radiology, UCSF, San Francisco, CA, USA; Department of Medicine, UCSF, San Francisco, CA, USA; Department of Psychiatry, UCSF, San Francisco, CA, USA; Center for Imaging of Neurodegenerative Diseases (CIND), Department Veterans Affairs Medical Center, San Francisco, CA, USA.
Paul M ThompsonDepartment of Neurology, Neuroscience Graduate Program, UCLA School of Medicine, Los Angeles, CA, USA; Department of Neurology, Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Department of Neurology, USC, Los Angeles, CA, USA; Department of Psychiatry, USC, Los Angeles, CA, USA; Department of Radiology, USC, Los Angeles, CA, USA; Department of Engineering, USC, Los Angeles, CA, USA; Department of Pediatrics, USC, Los Angeles, CA, USA; Department of Ophthalmology, USC, Los Angeles, CA, USA. Electronic address: pthomp@usc.edu.
Alzheimer's Disease Neuroimaging Initiative
Mayo Clinic · USUniversity of Southern California · USSan Francisco VA Medical Center · USUniversity of California, Los Angeles · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
UCLA ALZHEIMERS DISEASE RESEARCH CENTERP50AG016570 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BREDESEN, DALE E. · 1999 to 2014
$25.9M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Growth factors, neuroinflammation, exercise, and brain integrityRF1AG041915 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2014
$2.9M
HARDI Mapping of Disease Effects on the BrainR01EB008432 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2009 to 2012
$2.6M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
DIGITAL REPRESENTATION AND VISUALIZATION OF HUMAN BRAINR01LM005639 · NLM · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOGA, ARTHUR W · 1995 to 2005
$1.8M
Comprehensive Training in Neuroimaging Fundamentals and ApplicationsR90DA023422 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COHEN, MARK STEVEN · 2006 to 2015
$1.7M
Comprehensive Training in Neuroimaging Fundamentals and ApplicationsT90DA022768 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COHEN, MARK STEVEN · 2006 to 2015
$1.5M
A Multidimensional Alzheimer's Disease Brain AtlasR01EB008281 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMPSON, PAUL M · 2007 to 2010
$1.4M
Empowering Personalized Medicine: Integrating Imaging, Genetics, and BiomarkersR01MH097268 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI, THOMPSON, PAUL M · 2012 to 2014
$1.3M
Canadian Institutes of Health ResearchNCRR NIH HHS R21 RR019771NCRR NIH HHS RR019771NIA NIH HHS AG016570NIA NIH HHS AG040060NIA NIH HHS K01 AG030514NIA NIH HHS P30 AG010129NIA NIH HHS P50 AG016570NIA NIH HHS P50 AG016570-019002NIA NIH HHS R01 AG040060NIA NIH HHS RF1 AG041915NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG024904-01NIBIB NIH HHS EB01651NIBIB NIH HHS R01 EB008281NIBIB NIH HHS R01 EB008432NIBIB NIH HHS R21 EB01651NIBIB NIH HHS U54 EB020403NIDA NIH HHS R90 DA022768NIDA NIH HHS R90 DA023422NIDA NIH HHS T90 DA022768NIDA NIH HHS T90 DA023422NIMH NIH HHS MH097268NIMH NIH HHS R01 MH097268NLM NIH HHS LM05639NLM NIH HHS R01 LM005639NLM NIH HHS R01 LM05639
6 · The paper itself

Abstract

The Alzheimer's Disease Neuroimaging Initiative recently implemented accelerated T1-weighted structural imaging to reduce scan times. Faster scans may reduce study costs and patient attrition by accommodating people who cannot tolerate long scan sessions. However, little is known about how scan acceleration affects the power to detect longitudinal brain change. Using tensor-based morphometry, no significant difference was detected in numerical summaries of atrophy rates from accelerated and nonaccelerated scans in subgroups of patients with Alzheimer's disease, early or late mild cognitive impairment, or healthy controls over a 6- and 12-month scan interval. Whole-brain voxelwise mapping analyses revealed some apparent regional differences in 6-month atrophy rates when comparing all subjects irrespective of diagnosis (n = 345). No such whole-brain difference was detected for the 12-month scan interval (n = 156). Effect sizes for structural brain changes were not detectably different in accelerated versus nonaccelerated data. Scan acceleration may influence brain measures but has minimal effects on tensor-based morphometry-derived atrophy measures, at least over the 6- and 12-month intervals examined here.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAtrophyBrainBrain MappingCognitive DysfunctionDiffusion Magnetic Resonance ImagingFemaleHumansMaleNeuroimagingTime FactorsAlzheimer's diseaseBiomarkerDrug trial enrichmentLongitudinalMRINeuroimagingScan accelerationTensor-based morphometry

Identifiers

PMID25444601
PMCPMC4374606
OpenAlexW2031448494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.