Trial reportThe Journal of pediatrics2015
Ezetimibe reduces plant sterol accumulation and favorably increases platelet count in sitosterolemia.
Trial report in The Journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 51 citations in OpenAlex.
- Thyroid Hormone Status in Sitosterolemia Is Modified by Ezetimibe.The Journal of pediatrics · 2017Trial
- Sitosterolemia Due to a New Combination ofJCEM case reports · 2025Article
- Sitosterolemia carrying both ABCG5 and HBA gene mutations: a case report and review of the literature.Journal of medical case reports · 2025Review
- [Clinical characteristics and treatment outcomes of adult patients with phytosterolemia presenting with Thrombocytopenia].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Phenotypes, Genotypes, Treatment, and Outcomes of 14 Children with Sitosterolemia at Vietnam National Children's Hospital.Journal of clinical medicine · 2025Article
- Two Cases of Sitosterolemia Falsely Diagnosed as Familial Hypercholesterolemia: Could Digging Deeper Have Avoided Harm?JCEM case reports · 2024Article
- Unmasking a Case of Sitosterolaemia: An Approach for Diagnosis and Management.European journal of case reports in internal medicine · 2024Article
- Hemolytic anemia and macrothrombocytopenia: A lipid problem?American journal of hematology · 2023Article
- Phytosterols and Cardiovascular Risk Evaluated against the Background of Phytosterolemia Cases-A German Expert Panel Statement.Nutrients · 2023Article
- Could Lowering Phytosterol Absorption as Part of Lipid-Lowering Therapy Have a Beneficial Effect on Residual Risk?Metabolites · 2023Article
- Sitosterolemia: A Case Report and a Concise Literature Review.Case reports in endocrinology · 2023Article
- Clinical and Genetic Analysis of a Family With Sitosterolemia Caused by a Novel ATP-Binding Cassette Subfamily G Member 5 Compound Heterozygous Mutation.Frontiers in cardiovascular medicine · 2022Article
- Diagnosis and Management of Sitosterolemia 2021.Journal of atherosclerosis and thrombosis · 2021Review
- Seventeen years of misdiagnosis in rare dyslipidaemia: a case report of sitosterolaemia in a young female.European heart journal. Case reports · 2021Article
- Remediation ofFrontiers in genetics · 2021Article
- Sitosterolemia: Four Cases of an Uncommon Cause of Hemolytic Anemia (Mediterranean Stomatocytosis with Macrothrombocytopenia).Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Article
- [Sitosterolemia (phytosterolemia)].Der Internist · 2019Review
- Sitosterolemia-10 years observation in two sisters.JIMD reports · 2019Article
- Clinical features and genetic analysis of childhood sitosterolemia: Two case reports and literature review.Medicine · 2019Review
- Progress and perspectives in plant sterol and plant stanol research.Nutrition reviews · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo assess if ezetimibe (EZE), a sterol-absorption inhibitor, improves platelet (PLT) count and size relative to its effect on plasma plant sterol (PS) in patients with sitosterolemia (STSL). STUDY
designPatients with STSL (5 males, 3 females, 16-56 years of age) receiving EZE intervention as part of their routine care participated in this study. EZE was discontinued for 14 weeks (off) and then resumed for another 14 weeks (on). Hematology variables along with plasma and red blood cells (RBC) PS and total cholesterol (TC) levels were measured at the end of each phase.
resultsEZE increased PLT count (23% ± 9%) and decreased mean PLT volume (MPV; 10% ± 3%, all P < .05). In patients off EZE, PLT counts inversely correlated (r = -0.96 and r = -0.91, all P < .01) with plasma and RBC PS to TC ratio (PS/TC), and MPV positively correlated (r = 0.91, P = .03 and r = 0.93, P = .02) with plasma and RBC PS/TC. EZE reduced plasma and RBC sitosterol (-35% ± 4% and -28% ± 3%), total PS (-37% ± 4% and -28% ± 3%, all P < .0001) levels, and PS/TC (-27% ± 4% and -28% ± 4%, P < .01).
conclusionsEZE reduces plasma and RBC PS levels, while increasing PLT count and decreasing MPV, and thereby may reduce the risk for bleeding in STSL. Plasma PS levels and ABCG5/ABCG8 genes should be analyzed in patients with unexplained hematologic abnormalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.