Observational studyOphthalmology2015
Longitudinal changes in quality of life and rates of progressive visual field loss in glaucoma patients.
Observational study in Ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 2 syntheses or guidelines pooled it, 177 citations in OpenAlex.
- Pooled it
- Tracing the natural course of visual acuity and quality of life in neovascular age-related macular degeneration: a systematic review and quality of life study.BMC ophthalmology · 2017Pooled it
- Comparison of postoperative cyclosporine 2.0% versus betamethasone 0.1% eye drops following trabeculectomy: A randomized clinical trial.Indian journal of ophthalmology · 2025Trial
- Differentiating stages of functional vision loss from glaucoma using the Disc Damage Likelihood Scale and cup:disc ratio.The British journal of ophthalmology · 2024Trial
- Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial.Lancet (London, England) · 2019Trial
- Treatment of Advanced Glaucoma Study: a multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma-study protocol.The British journal of ophthalmology · 2018Trial
- Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study.Scientific reports · 2018Trial
- Association between Intraocular Pressure and Rates of Retinal Nerve Fiber Layer Loss Measured by Optical Coherence Tomography.Ophthalmology · 2016Trial
- Long-term Safety and Efficacy of Latanoprostene Bunod 0.024% in Japanese Subjects with Open-Angle Glaucoma or Ocular Hypertension: The JUPITER Study.Advances in therapy · 2016Trial
- Visual impairment and vision-related quality of life in the Early Manifest Glaucoma Trial after 20 years of follow-up.Acta ophthalmologica · 2015Trial
- Beyond intraocular pressure: introducing a novel glaucoma-specific PROM for evaluating outcomes after IStent inject implantation combined with phacoemulsification cataract surgery.Scientific reports · 2026Article
- Eye-tracking reading patterns across different interventions in glaucoma patients versus controls.Scientific reports · 2026Article
- Artificial Intelligence-Guided Endpoint Selection for Neuroprotection Trials in Glaucoma.American journal of ophthalmology · 2026Article
- Eye-Tracking Reading Patterns as Correlates of Clinical Measures in Glaucoma.Ophthalmic research · 2026Article
- Development and Evaluation of an Artificial Intelligence Model to Set Target IOP for Glaucoma.American journal of ophthalmology · 2025Article
- Differential Effects of Corneal Biomechanics on Superficial and Deep Vessel Density and Their Association with Central Visual Function in Glaucoma Patients with Myopia.Journal of clinical medicine · 2025Article
- Differential Impact of Central and Global Visual Field Progression on Quality of Life in Glaucoma.American journal of ophthalmology · 2025Article
- Vision-Related Quality of Life Among Glaucoma Patients in Saudi Arabia:Sultan Qaboos University medical journal · 2025Article
- Benefits of Explorative Saccade Training in Patients with Advanced Glaucomatous Visual Field Defects-A Randomized, Placebo-Controlled Study.Journal of clinical medicine · 2025Article
- Longitudinal Simulated Driving Performance and Rates of Progressive Visual Field Loss in Glaucoma.Translational vision science & technology · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
purposeTo evaluate the association between longitudinal changes in quality of life (QoL) and rates of progressive visual field loss in glaucoma.
designProspective observational cohort study.
participantsWe recruited 322 eyes of 161 patients with glaucomatous visual field loss from the Diagnostic Innovations Glaucoma Study followed for an average of 3.5±0.7 years.
methodsAll subjects had National Eye Institute Visual Function Questionnaire (NEI VFQ)-25 performed annually and standard automated perimetry (SAP) at 6-month intervals. Subjects were included if they had a minimum of 2 NEI VFQ-25 and ≥5 SAP during follow-up. Evaluation of rates of visual field change was performed using the mean sensitivity (MS) of the integrated binocular visual field (BVF). Rasch analysis was performed to obtain final scores of disability as measured by the NEI VFQ-25. A joint longitudinal multivariate mixed model was used to investigate the association between change in NEI VFQ-25 Rasch-calibrated scores and change in BVF sensitivity. Potentially confounding socioeconomic and clinical variables also were analyzed.
main outcome measuresThe relationship between change in NEI VFQ-25 Rasch-calibrated scores and change in binocular SAP MS.
resultsThere was a significant correlation between change in the NEI VFQ-25 Rasch scores during follow-up and change in binocular SAP sensitivity. Each 1-dB change in binocular SAP MS per year was associated with a change of 2.9 units per year in the NEI VFQ-25 Rasch scores during the follow-up period (R(2) = 26%; P<0.001). Eyes with more severe disease at baseline were also more likely to have a decrease in NEI VFQ-25 scores during follow-up (P<0.001). For subjects with the same amount of change in SAP sensitivity, those with shorter follow-up times had larger changes in NEI VFQ-25 scores (P = 0.005). A multivariable model containing baseline and rate of change in binocular MS had an adjusted R(2) of 50% in predicting change in NEI VFQ-25 scores.
conclusionsBaseline severity, magnitude, and rates of change in BVF sensitivity were associated with longitudinal changes in QoL of glaucoma patients. Assessment of longitudinal visual field changes may help to identify patients at greater risk for developing disability from the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.