Evidence map›Paper›PMID 25443798›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2015

Endogenous sex steroid hormones and glucose in a South-Asian population without diabetes: the Metabolic Syndrome and Atherosclerosis in South-Asians Living in America pilot study.

B L Needham, C Kim, B Mukherjee, P Bagchi, F Z Stanczyk, A M Kanaya

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

B L NeedhamDepartment of Epidemiology and Center for Social Epidemiology and Population Health, University of Michigan, Ann Arbor, MI, USA.
C KimDepartments of Medicine and Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
B MukherjeeDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
P BagchiDepartment of Statistics, University of Michigan, Ann Arbor, MI, USA.
F Z StanczykDepartment of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA.
A M KanayaDepartments of Medicine, Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
University of Michigan–Ann Arbor · USUniversity of California, San Francisco · USUniversity of Southern California · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Mediators of Atherosclerosis in South Asians Living in AmericaR01HL093009 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2010 to 2018
$5.4M
Ectopic fat and atherosclerosis in South AsiansK24HL112827 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2013 to 2022
$1.2M
Metabolic Syndrome and Atherosclerosis in South AsiansK23HL080026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2006 to 2008
$442k
NCATS NIH HHS UL1 TR000004NCRR NIH HHS UL1 RR024131NCRR NIH HHS UL1 RR024131-01NHLBI NIH HHS K23 HL080026NHLBI NIH HHS K23 HL080026-01NHLBI NIH HHS K24 HL112827NHLBI NIH HHS R01 HL 093009NHLBI NIH HHS R01 HL093009NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIEHS NIH HHS P30 ES017885
6 · The paper itself

Abstract

aimsTo examine the associations between endogenous sex steroid hormones (oestradiol, testosterone and sex hormone-binding globulin) with diabetes risk in a South-Asian population living in the USA.

methodsWe used data from the Metabolic Syndrome and Atherosclerosis in South-Asians Living in America pilot study. The analytical sample included 60 women and 45 men of Asian Indian origin living in the San Francisco Bay Area, who were free from diabetes and cardiovascular disease and did not use exogenous sex steroids. Sex steroid hormone levels were assessed by validated conventional radioimmunoassays, and visceral and hepatic adiposity were assessed by computed tomography. We used multivariable regression to examine the association between endogenous sex steroid hormone levels (log-transformed) and fasting glucose and 2-h glucose levels in a series of sex-stratified models adjusted for age, waist circumference, visceral and hepatic adiposity, and insulin resistance.

resultsIn age-adjusted models, lower levels of sex hormone-binding globulin (β = -0.18, 95% CI -0.30, -0.06) and higher levels of free testosterone (β = 0.14, 95% CI 0.02, 0.26) were associated with elevated fasting glucose levels in South-Asian women, whereas lower levels of sex hormone-binding globulin (β = -0.14, 95% CI -0.26, -0.02) and lower levels of total testosterone (β = -0.12, 95% CI -0.24, 0.00) were associated with elevated fasting glucose levels in South-Asian men. Adjustment for waist circumference, visceral adiposity and insulin resistance attenuated most of these associations, while adjustment for hepatic adiposity strengthened some of the observed associations. Similar results were found for 2-h glucose levels.

conclusionsResults were consistent with previous research, which suggests that endogenous sex steroid hormones are a risk factor for diabetes across multiple race/ethnic groups. Additional studies are needed to determine whether visceral fat is a mediator or confounder of associations between sex steroid hormone and glucose levels.

Indexed as

AgedAged, 80 and overAsianBlood GlucoseCross-Sectional StudiesEstradiolFemaleHumansMaleMiddle AgedPilot ProjectsSan FranciscoSex DistributionSex Hormone-Binding GlobulinTestosteroneBlood GlucoseEstradiolSex Hormone-Binding GlobulinTestosterone

Identifiers

PMID25443798
PMCPMC4449322
OpenAlexW2031246762

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.