Serum amyloid A proteins take retinol for a ride.

Daria Esterházy, Daniel Mucida

Open access · greenAbstract readComment

In one paragraph

Article in Trends in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.1field-weighted citation impact, top 46% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Modulation of Intestinal Immune and Barrier Functions by Vitamin A: Implications for Current Understanding of Malnutrition and Enteric Infections in Children.Nutrients · 2018
Review

4 · The record

Corrections and comments

Comment on
Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection.2014

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Daria EsterházyLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA.

Daniel MucidaLaboratory of Mucosal Immunology, The Rockefeller University, New York, NY, USA. Electronic address: mucida@rockefeller.edu.

Rockefeller University · US

Funding

INTESTINAL REGULATION OF ThPOK EXPRESSION AND CD4 HELPER T CELL FUNCTIONR01DK093674 · NIDDK · ROCKEFELLER UNIVERSITY · PI Daniel S Mucida · 2013 to 2026

$7.0M

Antigen presentation in the intestine: initiating events in oral toleranceR56AI119062 · NIAID · ROCKEFELLER UNIVERSITY · PI MUCIDA, DANIEL S · 2015 to 2015

$424k

NIAID NIH HHS R56 AI119062NIDDK NIH HHS R01 DK093674

6 · The paper itself

Abstract

Vitamin A plays pleiotropic roles in the immune system. A recent eLife paper by Hooper and colleagues shows that hepatic and intestinal serum amyloid A proteins, which are induced in response to infection, can transport vitamin A metabolites to tissues and thus impact immune responses both locally and systemically.

Indexed as

AnimalsHumansRetinol-Binding ProteinsSalmonella InfectionsSerum Amyloid A ProteinVitamin ARetinol-Binding ProteinsSerum Amyloid A ProteinVitamin A

Identifiers

PMID25443493

DOI10.1016/j.it.2014.10.001

PMCPMC4380118

OpenAlexW2062679365

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.