ArticleCell and tissue research1989
Intracellular signals trigger ultrastructural events characteristic of meiotic maturation in oocytes of Xenopus laevis.
Article in Cell and tissue research, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 36 citations in OpenAlex.
- Changes in gene expression associated with oocyte meiosis after Obox4 RNAi.Clinical and experimental reproductive medicine · 2011Article
- Progesterone receptors: form and function in brain.Frontiers in neuroendocrinology · 2008Review
- A role for myosin 1e in cortical granule exocytosis in Xenopus oocytes.The Journal of biological chemistry · 2007Article
- Rapid report: a novel technique for quantitative measurement of free Ca2+ concentration in rat heart mitochondria.The Journal of physiology · 1999Article
- Nuclear pore complex assembly studied with a biochemical assay for annulate lamellae formation.The Journal of cell biology · 1995Article
- Parallel pathways of cell cycle control during Xenopus egg activation.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Cortical membrane-trafficking during the meiotic resumption of Xenopus laevis oocytes.Cell and tissue research · 1991Article
- Activators of protein kinase C trigger cortical granule exocytosis, cortical contraction, and cleavage furrow formation in Xenopus laevis oocytes and eggs.The Journal of cell biology · 1989Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Oocytes of Xenopus laevis were treated with agents which induce individual intracellular signals normally evoked during the process of meiotic maturation. Ultrastructural analysis of these oocytes allowed identification of specific second messengers that individually trigger single ultrastructural changes characteristic of the meiotic maturation process: Manipulation of intracellular cAMP levels induced changes in cortical granule position. Cytoplasmic alkalinization triggered a disruption of the annulate lamellae, a specialized organelle in the periphery of oocytes. Activation of protein kinase C caused rapid formation of a cortical endoplasmic reticulum and subsequent disruption of cortical granules. Manipulation of transmembrane calcium flux had varied results dependent upon the agent employed. Two of the treatments, Verapamil and zero external calcium, induced a reorganization in the oocyte periphery. The results indicate that these ultrastructural events are under the control of specific intracellular signals known to be elicited during meiotic maturation.
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