ReviewTrends in cardiovascular medicine2015
Insights into cardiac conduction system formation provided by HCN4 expression.
Review in Trends in cardiovascular medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Novel insights into the substrate involved in maintenance of ventricular fibrillation: results from continuous multipolar mapping in a canine model.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Cardiac conduction system malformations in heterotaxy result from dysregulated Pitx2 expression.JCI insight · 2026Article
- Human iPSC-derived self-assembled cardiac organoids for evaluating drug developmental cardiotoxicity.Life medicine · 2025Article
- Molecular Regulation of Cardiac Conduction System Development.Current cardiology reports · 2024Review
- Quantitative proteomic profiling identifies global protein network dynamics in murine embryonic heart development.Developmental cell · 2023Article
- Novel Insights into the Sinoatrial Node in Single-Cell RNA Sequencing: From Developmental Biology to Physiological Function.Journal of cardiovascular development and disease · 2022Review
- Molecular Profiling of the Cardiac Conduction System: the Dawn of a New Era.Current cardiology reports · 2021Review
- Bioengineering Clinically Relevant Cardiomyocytes and Cardiac Tissues from Pluripotent Stem Cells.International journal of molecular sciences · 2021Review
- Inflammation of Conduction Tissue in Patients with Arrhythmic Phenotype of Myocarditis.Journal of clinical medicine · 2020Article
- Comprehensive Analysis and Co-Expression Network of mRNAs and lncRNAs in Pressure Overload-Induced Heart Failure.Frontiers in genetics · 2019Article
- ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes.Scientific reports · 2018Article
- A mutant HCN4 channel in a family with bradycardia, left bundle branch block, and left ventricular noncompaction.Heart and vessels · 2018Article
- Development of a Rat Model of Sick Sinus Syndrome Using Pinpoint Press Permeation.BioMed research international · 2018Article
- Development of the cardiac pacemaker.Cellular and molecular life sciences : CMLS · 2017Review
- Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis inCommunicative & integrative biology · 2017Article
- Zrf1 controls mesoderm lineage genes and cardiomyocyte differentiation.Cell cycle (Georgetown, Tex.) · 2016Article
- Probing the Electrophysiology of the Developing Heart.Journal of cardiovascular development and disease · 2016Review
- Segregation of Central Ventricular Conduction System Lineages in Early SMA+ Cardiomyocytes Occurs Prior to Heart Tube Formation.Journal of cardiovascular development and disease · 2016Article
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Specialized myocytes of the cardiac conduction system (CCS) are essential to coordinate sequential contraction of cardiac atria and ventricles. Anomalies of the CCS can result in lethal cardiac arrhythmias, including sick sinus syndrome and atrial or ventricular fibrillation. To develop future therapies and regenerative medicine aimed at cardiac arrhythmias, it is important to understand formation and function of distinct components of the CCS. Essential to this understanding is the development of CCS-specific markers. In this review, we briefly summarize available mouse models of CCS markers and focus on those involving the hyperpolarization cation-selective nucleotide-gated cation channel, HCN4, which selectively marks all components of the specialized CCS in adult heart. Recent studies have revealed, however, that HCN4 expression during development is highly dynamic in cardiac precursors. These studies have offered insights into the contributions of the first and second heart field to myocyte and conduction system lineages and suggested the timing of allocation of specific conduction system precursors during development. Altogether, they have highlighted the utility of HCN4 as a cell surface marker for distinct components of the CCS at distinct stages of development, which can be utilized to facilitate purification and characterization of CCS precursors in mouse and human model systems and pave the way for regenerative therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.