ArticleThe Canadian journal of cardiology2014
T1 measurements for detection of expansion of the myocardial extracellular volume in chronic obstructive pulmonary disease.
Article in The Canadian journal of cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Point estimate and reference normality interval of MRI-derived myocardial extracellular volume in healthy subjects: a systematic review and meta-analysis.European radiology · 2019Pooled it
- Review of the prevalence, pathogenesis and management of OSA-COPD overlap.Sleep & breathing = Schlaf & Atmung · 2022Review
- Effects of COPD on Left Ventricular and Left Atrial Deformation in Patients with Acute Myocardial Infarction: Strain Analysis Using Speckle-Tracking Echocardiography.Journal of clinical medicine · 2022Article
- Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure.JACC. Cardiovascular imaging · 2021Article
- Cardiac extracellular volume fraction in cats with preclinical hypertrophic cardiomyopathy.Journal of veterinary internal medicine · 2021Article
- The Role of Stress Echocardiography in the Early Detection of Diastolic Dysfunction in Non-Severe Chronic Obstructive Pulmonary Disease Patients.Arquivos brasileiros de cardiologia · 2021Article
- Sleep disordered breathing and chronic obstructive pulmonary disease: a narrative review on classification, pathophysiology and clinical outcomes.Journal of thoracic disease · 2020Review
- COPD and acute myocardial infarction.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Effects of bone marrow‑derived mesenchymal stem cell transplantation on chronic obstructive pulmonary disease/obstructive sleep apnea overlap syndrome in rats.Molecular medicine reports · 2019Article
- Stress echocardiography for left ventricular diastolic dysfunction detection in patients with non-severe chronic obstructive pulmonary disease: a cross-sectional study.Croatian medical journal · 2019Article
- Advanced imaging modalities to detect cardiotoxicity.Current problems in cancer · 2018Review
- Research Priorities in Pathophysiology for Sleep-disordered Breathing in Patients with Chronic Obstructive Pulmonary Disease. An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2018Review
- Chest pain in patients with COPD: the fascia's subtle silence.International journal of chronic obstructive pulmonary disease · 2018Review
- Sleep in Chronic Obstructive Pulmonary Disease: Evidence Gaps and Challenges.Canadian respiratory journal · 2016Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundWe aimed to assess whether chronic obstructive pulmonary disease (COPD) is associated with expansion of the myocardial extracellular volume (ECV) using T1 measurements.
methodsAdult COPD patients Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 2 or higher and free of known cardiovascular disease were recruited. All study patients underwent measures of pulmonary function, 6-minute walk test, serum measures of inflammation, overnight polysomnography, and a contrast cardiac magnetic resonance study.
resultsEight patients with COPD were compared with 8 healthy control subjects. The mean predicted forced expiratory volume at 1 second of COPD subjects was 68%. Compared with control subjects, patients had normal left ventricular (LV) and right ventricular size, mass, and function. However, compared with control subjects, the LV remodelling index (median, 0.87; interquartile range [IQR], 0.71-1.14; vs median, 0.62; IQR, 0.60-0.77; P ¼ 0.03) and active left atrial emptying fraction was increased (median, 46; IQR, 41-49; vs median, 38; IQR, 33-43; P ¼ 0.005), and passive left atrial emptying fraction was reduced (median, 24; IQR, 20-30; vs median, 44; IQR, 31-51; P ¼ 0.007). The ECV was increased in patients with COPD (median, 0.32; IQR, 0.05; vs median, 0.27; IQR, 0.05; P = 0.001). The ECV showed a strong positive association with LV remodelling (r = 0.72; P = 0.04) and an inverse association with the 6-minute walk duration (r = -0.79; P = 0.02) and passive left atrial emptying fraction (r = -0.68; P = 0.003).
conclusionsExpansion of the ECV, suggestive of diffuse myocardial fibrosis, is present in COPD and is associated with LV remodelling, and reduced left atrial function and exercise capacity.
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