Evidence map›Paper›PMID 25442171›Full record

ReviewAlcohol (Fayetteville, N.Y.)2015

Sleep and circadian contributions to adolescent alcohol use disorder.

Brant P Hasler, Adriane M Soehner, Duncan B Clark

Abstract readReview
In one paragraph

Review in Alcohol (Fayetteville, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. Effect of daily discrimination on naturalistic sleep health features in young adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024
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  18. Review
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brant P HaslerDepartment of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. Electronic address: haslerbp@upmc.edu.
Adriane M SoehnerDepartment of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
Duncan B ClarkDepartment of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.

Funding

TRANSLATION MODULEP50DA005605 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RIDENOUR, TY A · 1989 to 2014
$25.7M
NCANDA Research Project Site: University of Pittsburgh (NCANDA-PITT)U01AA021690 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DUNCAN B. CLARK, BEATRIZ LUNA · 2012 to 2026
$7.6M
Northwest Pennsylvania Adolescent Alcohol Research Cooperative (Phase II)R01AA016482 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLARK, DUNCAN B. · 2010 to 2013
$2.4M
Northwest Pennsylvania Adolescent Alcohol Research Cooperative (Phase II)U01AA016482 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLARK, DUNCAN B. · 2006 to 2009
$1.5M
Circadian misalignment and reward function: a novel pathway to substance useK01DA032557 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HASLER, BRANT P. · 2012 to 2016
$777k
NIAAA NIH HHS R01 AA016482NIAAA NIH HHS R01AA016482NIAAA NIH HHS U01 AA016482NIAAA NIH HHS U01 AA021690NIAAA NIH HHS U01AA021690NIDA NIH HHS K01 DA032557NIDA NIH HHS K01DA032557NIDA NIH HHS P50 DA005605NIDA NIH HHS P50DA05605
6 · The paper itself

Abstract

Adolescence is a time of marked changes across sleep, circadian rhythms, brain function, and alcohol use. Starting at puberty, adolescents' endogenous circadian rhythms and preferred sleep times shift later, often leading to a mismatch with the schedules imposed by secondary education. This mismatch induces circadian misalignment and sleep loss, which have been associated with affect dysregulation, increased drug and alcohol use, and other risk-taking behaviors in adolescents and adults. In parallel to developmental changes in sleep, adolescent brains are undergoing structural and functional changes in the circuits subserving the pursuit and processing of rewards. These developmental changes in reward processing likely contribute to the initiation of alcohol use during adolescence. Abundant evidence indicates that sleep and circadian rhythms modulate reward function, suggesting that adolescent sleep and circadian disturbance may contribute to altered reward function, and in turn, alcohol involvement. In this review, we summarize the relevant evidence and propose that these parallel developmental changes in sleep, circadian rhythms, and neural processing of reward interact to increase risk for alcohol use disorder (AUD).

Indexed as

AlcoholismRewardSchoolsUnderage DrinkingAdolescentAdolescent DevelopmentBrainChronobiology DisordersCircadian RhythmHumansRisk FactorsRisk-TakingSleepSleep Wake DisordersTime FactorsAdolescenceAlcohol use disordersCircadian rhythmsReward functionSleep

Identifiers

PMID25442171
PMCPMC4424185

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.