ArticleNeurobiology of aging2015
Occipital sources of resting-state alpha rhythms are related to local gray matter density in subjects with amnesic mild cognitive impairment and Alzheimer's disease.
Article in Neurobiology of aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer's disease progression: a systematic review.Alzheimer's research & therapy · 2024Pooled it
- The effects of different acetylcholinesterase inhibitors on EEG patterns in patients with Alzheimer's disease: A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Source-space EEG alpha activity reveals brain age gaps due to neurodegeneration and disparity.Communications biology · 2026Article
- Quantitative EEG signatures of power and functional connectivity alterations in Alzheimer's disease and frontotemporal dementia.Scientific reports · 2026Article
- EEG-based detection of early functional brain changes in subjective cognitive decline: a prospective cohort study.Alzheimer's research & therapy · 2025Article
- Neurofeedback-Enhanced Working Memory Training: A Proof-of-Concept for Reversing Age-Related Neural Slowing in Older Adults.medRxiv : the preprint server for health sciences · 2025Article
- Fear Detection Using Electroencephalogram and Artificial Intelligence: A Systematic Review.Brain sciences · 2025Review
- Stable EEG Spatiospectral Patterns Estimated in Individuals by Group Information Guided NMF.Brain topography · 2025Article
- BPEN: Brain Posterior Evidential Network for trustworthy brain imaging analysis.Neural networks : the official journal of the International Neural Network Society · 2025Article
- Ongoing Dynamics of Peak Alpha Frequency Characterize Hypnotic Induction in Highly Hypnotic-Susceptible Individuals.Brain sciences · 2024Article
- Changes in Spatiotemporal Dynamics of Default Network Oscillations between 19 and 29 Years of Age.Brain sciences · 2024Article
- Quantitative electroencephalography (qEEG), apolipoprotein A-I (APOA-I), and apolipoprotein epsilon 4 (APOE ɛ4) alleles for the diagnosis of mild cognitive impairment and Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Distinct Spectral Profiles of Awake Resting EEG in Disorders of Consciousness: The Role of Frequency and Topography of Oscillations.Brain topography · 2024Article
- Brain-wide functional connectivity alterations and their cognitive correlates in subjective cognitive decline.Frontiers in neuroscience · 2024Article
- Neurophysiological markers in community-dwelling older adults with mild cognitive impairment: an EEG study.Alzheimer's research & therapy · 2023Article
- Beta to theta power ratio in EEG periodic components as a potential biomarker in mild cognitive impairment and Alzheimer's dementia.Alzheimer's research & therapy · 2023Article
- Toward the Identification of Neurophysiological Biomarkers for Alzheimer's Disease in Down Syndrome: A Potential Role for Cross-Frequency Phase-Amplitude Coupling Analysis.Aging and disease · 2023Review
- Attempting to counteract vigilance decrement in older adults with brain stimulation.Frontiers in neuroergonomics · 2023Article
- Patients with Alzheimer's disease dementia show partially preserved parietal 'hubs' modeled from resting-state alpha electroencephalographic rhythms.Frontiers in aging neuroscience · 2023Article
- Virtual brain simulations reveal network-specific parameters in neurodegenerative dementias.Frontiers in aging neuroscience · 2023Article
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Authors and funding
23 authors at 15 institutions in 3 countries.
Funding
Abstract
Occipital sources of resting-state electroencephalographic (EEG) alpha rhythms are abnormal, at the group level, in patients with amnesic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Here, we evaluated the hypothesis that amplitude of these occipital sources is related to neurodegeneration in occipital lobe as measured by magnetic resonance imaging. Resting-state eyes-closed EEG rhythms were recorded in 45 healthy elderly (Nold), 100 MCI, and 90 AD subjects. Neurodegeneration of occipital lobe was indexed by weighted averages of gray matter density, estimated from structural MRIs. EEG rhythms of interest were alpha 1 (8-10.5 Hz) and alpha 2 (10.5-13 Hz). EEG cortical sources were estimated by low-resolution brain electromagnetic tomography. Results showed a positive correlation between occipital gray matter density and amplitude of occipital alpha 1 sources in Nold, MCI, and AD subjects as a whole group (r = 0.3, p = 0.000004, N = 235). Furthermore, there was a positive correlation between the amplitude of occipital alpha 1 sources and cognitive status as revealed by Mini Mental State Examination score across all subjects (r = 0.38, p = 0.000001, N = 235). Finally, amplitude of occipital alpha 1 sources allowed a moderate classification of individual Nold and AD subjects (sensitivity: 87.8%; specificity: 66.7%; area under the receiver operating characteristic curve: 0.81). These results suggest that the amplitude of occipital sources of resting-state alpha rhythms is related to AD neurodegeneration in occipital lobe along pathologic aging.
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