ArticleBiological psychiatry2015
Maternal immune activation in nonhuman primates alters social attention in juvenile offspring.
Article in Biological psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
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Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Sickness and the Social Brain: Love in the Time of COVID.Frontiers in psychiatry · 2021Pooled it
- Prenatal maternal immune activation triggers lasting cell-specific transcriptomic dysregulation in the amygdala of primate offspring.Molecular psychiatry · 2026Article
- Genetically Modified Primate Models for Brain Disorder Research.Neuroscience bulletin · 2026Review
- Prenatal and postnatal effects of gestational immune activation on synaptic and neurodevelopmental pathways via epigenetic mechanisms.Translational psychiatry · 2026Article
- Sex-specific vulnerabilities in early human neurodevelopment following SARS-CoV-2-induced maternal immune activation.European child & adolescent psychiatry · 2026Article
- Maternal factors contributing to variability in gut microbiota and gastrointestinal function in autism spectrum disorders.World journal of psychiatry · 2025Review
- Maternal immune activation alters infant attentional processing in a nonhuman primate model.Brain, behavior, & immunity - health · 2025Article
- The microbiome as a modulator of neurological health across the maternal-offspring interface.The Journal of clinical investigation · 2025Review
- Maternal prenatal immune activation associated with brain tissue microstructure and metabolite concentrations in newborn infants.Brain, behavior, and immunity · 2024Article
- Differential effects of purified low molecular weight Poly(I:C) in the maternal immune activation model depend on the laboratory environment.Translational psychiatry · 2024Article
- Viral infections in pregnancy and impact on offspring neurodevelopment: mechanisms and lessons learned.Pediatric research · 2024Review
- GABA system as the cause and effect in early development.Neuroscience and biobehavioral reviews · 2024Review
- Prenatal SARS-CoV-2 infection results in neurodevelopmental and behavioral outcomes in mice.JCI insight · 2024Article
- Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders.Nature immunology · 2024Review
- Maximizing valid eye-tracking data in human and macaque infants by optimizing calibration and adjusting areas of interest.Behavior research methods · 2024Article
- Human brain organoid model of maternal immune activation identifies radial glia cells as selectively vulnerable.Molecular psychiatry · 2023Article
- Endophenotype trait domains for advancing gene discovery in autism spectrum disorder.Journal of neurodevelopmental disorders · 2023Review
- Beyond TORCH: A narrative review of the impact of antenatal and perinatal infections on the risk of disability.Neuroscience and biobehavioral reviews · 2023Review
- Extracellular free water elevations are associated with brain volume and maternal cytokine response in a longitudinal nonhuman primate maternal immune activation model.Molecular psychiatry · 2023Article
- Increased Striatal Presynaptic Dopamine in a Nonhuman Primate Model of Maternal Immune Activation: A Longitudinal Neurodevelopmental Positron Emission Tomography Study With Implications for Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSickness during pregnancy is associated with an increased risk of offspring neurodevelopmental disorders. Rodent models have played a critical role in establishing causal relationships and identifying mechanisms of altered brain and behavior development in pups prenatally exposed to maternal immune activation (MIA). We recently developed a novel nonhuman primate model to bridge the gap between human epidemiological studies and rodent models of prenatal immune challenge. Our initial results demonstrated that rhesus monkeys given the viral mimic synthetic double-stranded RNA (polyinosinic:polycytidylic acid stabilized with poly-l-lysine) during pregnancy produce offspring with abnormal repetitive behaviors, altered communication, and atypical social interactions.
methodsWe utilized noninvasive infrared eye tracking to further evaluate social processing capabilities in a subset of the first trimester MIA-exposed offspring (n = 4) and control animals (n = 4) from our previous study.
resultsAs juveniles, the MIA offspring differed from control animals on several measures of social attention, particularly when viewing macaque faces depicting the fear grimace facial expression. Compared with control animals, MIA offspring had a longer latency before fixating on the eyes, had fewer fixations directed at the eyes, and spent less total time fixating on the eyes of the fear grimace images.
conclusionsIn the rhesus monkey model, exposure to MIA at the end of the first trimester results in abnormal gaze patterns to salient social information. The use of noninvasive eye tracking extends the findings from rodent MIA models to more human-like behaviors resembling those in both autism spectrum disorder and schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.