Evidence map›Paper›PMID 25441679›Full record

ArticleJournal of vascular surgery2014

Relationship between kidney disease and endothelial function in peripheral artery disease.

Karen C Chong, Christopher D Owens, Meyeon Park, Hugh F Alley, W John Boscardin, Michael S Conte, Warren J Gasper, S Marlene Grenon

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of vascular surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01310270 (The Effects of Omega-3 Fatty Acids Supplementation on Endothelial Function and Inflammation), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01310270 nacompletednot on this map

The Effects of Omega-3 Fatty Acids Supplementation on Endothelial Function and Inflammation

TypeinterventionalSponsorUniversity of California, San FranciscoRan2011 to 2018Enrolled180ConditionsPeripheral Arterial DiseaseArmsPro-Omega, Omega 3 Fatty Acid
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Karen C ChongDivision of Vascular and Endovascular Surgery, University of California, San Francisco, Calif; VIPERx Laboratory, University of California, San Francisco, Calif.
Christopher D OwensDivision of Vascular and Endovascular Surgery, University of California, San Francisco, Calif; VIPERx Laboratory, University of California, San Francisco, Calif; Division of Vascular Surgery, Veterans Affairs Medical Center, San Francisco, Calif.
Meyeon ParkDepartment of Nephrology, University of California, San Francisco, Calif.
Hugh F AlleyDivision of Vascular and Endovascular Surgery, University of California, San Francisco, Calif; VIPERx Laboratory, University of California, San Francisco, Calif.
W John BoscardinDepartments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, Calif.
Michael S ConteDivision of Vascular and Endovascular Surgery, University of California, San Francisco, Calif.
Warren J GasperDivision of Vascular and Endovascular Surgery, University of California, San Francisco, Calif; VIPERx Laboratory, University of California, San Francisco, Calif; Division of Vascular Surgery, Veterans Affairs Medical Center, San Francisco, Calif.
S Marlene GrenonDivision of Vascular and Endovascular Surgery, University of California, San Francisco, Calif; VIPERx Laboratory, University of California, San Francisco, Calif; Division of Vascular Surgery, Veterans Affairs Medical Center, San Francisco, Calif. Electronic address: marlene.grenon@ucsfmedctr.org.
University of California, San Francisco · USSan Francisco VA Medical Center · US

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
CTSA: K12 COMPONENTKL2RR024130 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$19.3M
Effects of fish oil on inflammation and vascular function in claudicantsK23HL122446 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRENON, MARLENE · 2014 to 2017
$806k
NCATS NIH HHS UL1 TR000004NCRR NIH HHS KL2 RR024130NCRR NIH HHS KL2RR024130NHLBI NIH HHS K23 HL122446NIA NIH HHS P30 AG044281
6 · The paper itself

Abstract

objectiveWe have previously shown that peripheral artery disease (PAD) is associated with marked impairment of endothelial function (EF). Given that poor EF is associated with functional status of PAD patients as well as with increased morbidity and mortality in patients undergoing vascular procedures, determination of factors associated with poor EF in a PAD cohort is important. We hypothesized that decreased kidney function is associated with impaired EF in patients with PAD.

methodsThis was a cross-sectional study of PAD patients presenting to a vascular surgery outpatient clinic at the San Francisco Veterans Affairs Medical Center including patients enrolled in the OMEGA-PAD I trial (NCT01310270) and the OMEGA-PAD Cohort. Brachial artery flow-mediated vasodilation was performed to assess EF. Kidney function was characterized by estimated glomerular filtration rate with the abbreviated Modification of Diet in Renal Disease formula. Linear regression was performed to assess the relationship between EF and kidney function in claudicants.

resultsNinety-seven patients with intermittent claudication participated in this study. Mean age was 69 ± 8 years, 97% were male, and 79% were white. Comorbidities included hypertension (91%), dyslipidemia (87%), coronary artery disease (42%), and diabetes mellitus (38%). Mean ankle-brachial index was 0.73 ± 0.14 and mean flow-mediated vasodilation was 7.0% ± 3.8%, indicating impaired EF. Linear regression showed an association between kidney function and EF (by 10 mL/min/1.73 m(2); β, 0.12; confidence interval, 0.05-0.20; P = .001). After multivariable regression adjusting for age, race, log tumor necrosis factor α, hypertension, dyslipidemia, and diabetes, estimated glomerular filtration rate remained significantly associated with EF (P = .033).

conclusionsIn patients with PAD, decreased kidney function is associated with endothelial dysfunction. Further longitudinal studies are needed to better understand the impact of kidney function on PAD progression and the role of endothelial dysfunction in this process.

Indexed as

AgedBrachial ArteryComorbidityCross-Sectional StudiesEndothelium, VascularFemaleGlomerular Filtration RateHumansIntermittent ClaudicationKidneyKidney DiseasesLinear ModelsMaleMiddle AgedMultivariate AnalysisPeripheral Arterial Disease

Identifiers

PMID25441679
PMCPMC4254442
OpenAlexW1971832229

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.