ArticleMolecular plant pathology2015
A new point mutation in the iron-sulfur subunit of succinate dehydrogenase confers resistance to boscalid in Sclerotinia sclerotiorum.
Article in Molecular plant pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 77 citations in OpenAlex.
- Genetic Differentiation in the SdhC Subunit Confers Intrinsic Resistance to SDHI Fungicides in Fusarium asiaticum.Molecular plant pathology · 2026Article
- Identification and genomic characterization ofFrontiers in microbiology · 2024Article
- Identification of Male Sex-Related Genes Regulated byInternational journal of molecular sciences · 2023Article
- Mechanism of Pydiflumetofen Resistance inJournal of fungi (Basel, Switzerland) · 2022Article
- Molecular Mechanisms Underlying Fungicide Resistance in Citrus Postharvest Green Mold.Journal of fungi (Basel, Switzerland) · 2021Review
- Identification and Characterization of the Succinate Dehydrogenase Complex Iron Sulfur Subunit B Gene in the Oriental River Prawn,Frontiers in genetics · 2021Article
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- The selective antifungal activity of Drosophila melanogaster metchnikowin reflects the species-dependent inhibition of succinate-coenzyme Q reductase.Scientific reports · 2017Article
- Involvement of BcElp4 in vegetative development, various environmental stress response and virulence of Botrytis cinerea.Microbial biotechnology · 2017Article
- Using C. elegans Forward and Reverse Genetics to Identify New Compounds with Anthelmintic Activity.PLoS neglected tropical diseases · 2016Article
- BcMtg2 is required for multiple stress tolerance, vegetative development and virulence in Botrytis cinerea.Scientific reports · 2016Article
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Research has established that mutations in highly conserved amino acids of the succinate dehydrogenase (SDH) complex in various fungi confer SDH inhibitor (SDHI) resistance. For Sclerotinia sclerotiorum (Lib.) de Bary, a necrotrophic fungus with a broad host range and a worldwide distribution, boscalid resistance has been attributed to the mutation H132R in the highly conserved SdhD subunit protein of the SDH complex. In our previous study, however, only one point mutation, A11V in SdhB (GCA to GTA change in SdhB), was detected in S. sclerotiorum boscalid-resistant (BR) mutants. In the current study, replacement of the SdhB gene in a boscalid-sensitive (BS) S. sclerotiorum strain with the mutant SdhB gene conferred resistance. Compared with wild-type strains, BR and GSM (SdhB gene in the wild-type strain replaced by the mutant SdhB gene) mutants were more sensitive to osmotic stress, lacked the ability to produce sclerotia and exhibited lower expression of the pac1 gene. Importantly, the point mutation was not located in the highly conserved sequence of the iron-sulfur subunit of SDH. These results suggest that resistance based on non-conserved vs. conserved protein domains differs in mechanism. In addition to increasing our understanding of boscalid resistance in S. sclerotiorum, the new information will be useful for the development of alternative antifungal drugs.
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