Observational studyAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2015
Estimating time to ESRD using kidney failure risk equations: results from the African American Study of Kidney Disease and Hypertension (AASK).
Observational study in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Towards the best kidney failure prediction tool: a systematic review and selection aid.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020Pooled it
- Pooled it
- Using pharmacists to improve risk stratification and management of stage 3A chronic kidney disease: a feasibility study.BMC nephrology · 2016Trial
- Semiparametric Joint Modeling for Survival Analysis with Longitudinal Covariates.Journal of the American Statistical Association · 2026Article
- External validation, recalibration, and clinical utility of the kidney failure risk equation in patients with advanced CKD: a nationwide retrospective cohort analysis in Peru.BMC nephrology · 2025Article
- Japanese Patients' Perceptions of Shared Decision-Making in Renal Replacement Therapy.Kidney international reports · 2025Article
- Cardiovascular and Kidney Outcomes of Non-Diabetic CKD by Albuminuria Severity: Findings From the CRIC Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024Article
- Association of Kidney Function with Sodium-Glucose Co-Transporter 2 Inhibitor Discontinuation among US Veterans.Clinical journal of the American Society of Nephrology : CJASN · 2024Article
- Proteinuria, measured or estimated albuminuria for risk prediction in patients with chronic kidney disease?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Utility of the Kidney Failure Risk Equation and Estimated GFR for Estimating Time to Kidney Failure in Advanced CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023Article
- Predicting outcomes in chronic kidney disease: needs and preferences of patients and nephrologists.BMC nephrology · 2023Article
- Prevalence of renal and bone risk factors among individuals prescribed oral pre-exposure prophylaxis for HIV.IJID regions · 2023Article
- Article
- Article
- CKD Progression From the Time of Estimated GFR-Based Waitlist Eligibility and Racial Disparities in Transplant Access.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- Lessons learnt when accounting for competing events in the external validation of time-to-event prognostic models.International journal of epidemiology · 2022Article
- Nephrology Referral Based on Laboratory Values, Kidney Failure Risk, or Both: A Study Using Veterans Affairs Health System Data.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Observational
- Prediction of End-Stage Kidney Disease Using Estimated Glomerular Filtration Rate With and Without Race : A Prospective Cohort Study.Annals of internal medicine · 2022Observational
- A surprising journey into the conversion of urinary protein creatinine ratio to urinary albumin creatinine ratio as needed in the Kidney Failure Risk Equation.Clinical kidney journal · 2021Article
- Estimation of Albumin-Creatinine Ratio From Protein-Creatinine Ratio in Urine of Children and Adolescents With CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Article
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPlanning for renal replacement therapy, such as referral for arteriovenous fistula placement and transplantation, often is guided by level of estimated glomerular filtration rate (eGFR). The use of risk equations might enable more accurate estimation of time to end-stage renal disease (ESRD), thus improving patient care. STUDY
designProspective observational study. SETTING &
participants1,094 participants in the African American Study of Kidney Disease and Hypertension (AASK) cohort. PREDICTOR: Age, sex, urine protein-creatinine ratio ≥ 1g/g, APOL1 high-risk status, and 3-year antecedent eGFR decline. OUTCOME: Cumulative incidence of ESRD from 5 different starting points: eGFR of 30 and 15mL/min/1.73m(2) and 1-year ESRD risk of 5%, 10%, and 20%, estimated by a published 4-variable kidney failure risk equation.
results566 participants developed eGFR of 30mL/min/1.73m(2), 244 developed eGFR of 15mL/min/1.73m(2), and 437, 336, and 259 developed 1-year ESRD risks of 5%, 10%, and 20%, respectively. The 1-year cumulative incidence of ESRD was 4.3% from eGFR of 30mL/min/1.73m(2), 49.0% from eGFR of 15mL/min/1.73m(2), 6.7% from 5% ESRD risk, 15.0% from 10% ESRD risk, and 29% from 20% ESRD risk. From eGFR of 30mL/min/1.73m(2), there were several risk factors that predicted ESRD risk. From eGFR of 15mL/min/1.73m(2), only level of proteinuria did; median time to ESRD was 9 and 19 months in those with higher and lower proteinuria, respectively. Median times were less variable from corresponding ESRD risk thresholds. For example, median times to ESRD from 20% ESRD risk were 22 and 25 months among those with higher and lower proteinuria, respectively. LIMITATIONS: Relatively homogeneous population of African Americans with hypertensive kidney disease.
conclusionsResults of the present study suggest the potential benefit of incorporating kidney failure risk equations into clinical care, with selection of a specific threshold guided by its intended use.
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