ArticleSeminars in diagnostic pathology2014
Pathology and genetics of pancreatic neoplasms with acinar differentiation.
Article in Seminars in diagnostic pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- The response of pancreatic acinar cell carcinoma to platinum and olaparib therapy in a germline BRCA2 variant carrier: case report and literature review.Familial cancer · 2024Review
- RareWorld journal of clinical cases · 2023Article
- Metachronous metastatic pancreatoblastoma to the liver in an elderly patient misdiagnosed as pancreatic acinar cell carcinoma.BMJ case reports · 2022Article
- Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis.Clinical case reports · 2022Article
- Pancreatoblastomas and mixed and pure acinar cell carcinomas share epigenetic signatures distinct from other neoplasms of the pancreas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Solid pancreatic masses in children: A review of current evidence and clinical challenges.Frontiers in pediatrics · 2022Review
- [Rare pancreatic tumors].Der Pathologe · 2021Review
- Pancreatic panniculitis and elevated serum lipase in metastasized acinar cell carcinoma of the pancreas: A case report and review of literature.World journal of clinical cases · 2020Article
- Malignant epithelial/exocrine tumors of the pancreas.Pathologica · 2020Review
- Diagnosis and treatment of pancreatoblastoma in children: a retrospective study in a single pediatric center.Pediatric surgery international · 2019Article
- Cytopathology and ultrastructure identification of primary hepatic acinar cell carcinoma: Case report.International journal of surgery case reports · 2019Article
- Pancreatoblastoma: an Atypical Presentation and a Literature Review.Journal of gastrointestinal cancer · 2018Review
- Article
- A FISH assay efficiently screens for BRAF gene rearrangements in pancreatic acinar-type neoplasms.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.World journal of gastroenterology · 2017Review
- Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability.Nature communications · 2017Article
- Pancreatoblastoma With Metastatic Retroperitoneal Lymph Node and PET/CT.Clinical nuclear medicine · 2017Article
- Chronic inflammation initiates multiple forms of K-Ras-independent mouse pancreatic cancer in the absence of TP53.Oncogene · 2017Article
- Intraductal Tubulopapillary Neoplasm of the Pancreas: A Clinicopathologic and Immunohistochemical Analysis of 33 Cases.The American journal of surgical pathology · 2017Article
- Immunohistochemical analysis of the Wnt/β-catenin signaling pathway in pancreatic neuroendocrine neoplasms.World journal of gastrointestinal oncology · 2016Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Pancreatic neoplasms with acinar differentiation, including acinar cell carcinoma, pancreatoblastoma, and carcinomas with mixed differentiation, are distinctive pancreatic neoplasms with a poor prognosis. These neoplasms are clinically, pathologically, and genetically unique when compared to other more common pancreatic neoplasms. Most occur in adults, although pancreatoblastomas usually affect children under 10 years old. All of these neoplasms exhibit characteristic histologic features including a solid or acinar growth pattern, dense neoplastic cellularity, uniform nuclei with prominent nucleoli, and granular eosinophilic cytoplasm. Exocrine enzymes are detectable by immunohistochemistry and, for carcinomas with mixed differentiation, neuroendocrine or ductal lineage markers are also expressed. The genetic alterations of this family of neoplasms largely differ from conventional ductal adenocarcinomas, with only rare mutations in TP53, KRAS, and p16, but no single gene or neoplastic pathway is consistently altered in acinar neoplasms. Instead, there is striking genomic instability, and a subset of cases has mutations in the APC/β-catenin pathway, mutations in SMAD4, RAF gene family fusions, or microsatellite instability. Therapeutically targetable mutations are often present. This review summarizes the clinical and pathologic features of acinar neoplasms and reviews the current molecular data on these uncommon tumors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.