Evidence map›Paper›PMID 25440821›Full record

ArticleUrology2015

Quantification of asymptomatic kidney stone burden by computed tomography for predicting future symptomatic stone events.

Michael G Selby, Terri J Vrtiska, Amy E Krambeck, Cynthia H McCollough, Hisham E Elsherbiny, Eric J Bergstralh, John C Lieske, Andrew D Rule

Abstract read
In one paragraph

Article in Urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  9. Renal colic imaging: Are we Choosing Wisely?Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2023
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  16. Subsequent urinary stone events are predicted by the magnitude of urinary oxalate excretion in enteric hyperoxaluria.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Michael G SelbyDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
Terri J VrtiskaDepartment of Diagnostic Radiology, Mayo Clinic, Rochester, MN.
Amy E KrambeckDepartment of Urology, Mayo Clinic, Rochester, MN.
Cynthia H McColloughDepartment of Diagnostic Radiology, Mayo Clinic, Rochester, MN.
Hisham E ElsherbinyDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
Eric J BergstralhDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
John C LieskeDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.
Andrew D RuleDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; Division of Epidemiology, Mayo Clinic, Rochester, MN. Electronic address: rule.andrew@mayo.edu.

Funding

Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
VISUALIZATION AND PATHOPHYSIOLOGY OF RENAL STONE PRECURSOR LESIONSU54DK100227 · NIDDK · MAYO CLINIC ROCHESTER · PI LIESKE, JOHN C · 2013 to 2017
$6.3M
Mayo Clinic Urology O'Brien Research CenterP50DK083007 · NIDDK · MAYO CLINIC ROCHESTER · PI LIESKE, JOHN C · 2008 to 2012
$5.3M
NIA NIH HHS AG034676NIA NIH HHS R01 AG034676NIDDK NIH HHS DK100227NIDDK NIH HHS DK83007NIDDK NIH HHS P50 DK083007NIDDK NIH HHS U54 DK100227
6 · The paper itself

Abstract

objectiveTo find the optimal characterization of asymptomatic radiographic stone burden on computed tomography (CT) scans.

methodsA survey was sent to stone formers who underwent a CT scan while asymptomatic during a stone clinic evaluation. Symptomatic stone passage events after CT scan were detected by survey and medical record review. Radiographic stone burden was quantified by number of stones, largest stone diameter, automated total stone volume (TSV), and bilateral stones and then compared as predictors of stone events.

resultsThere were 550 stone formers; 43% had a stone event for a median of 4.7 years after the CT scan. Stone burden by quartiles was 0-1, 2-3, 4-6, and ≥7 for number of stones; 0-2, 3-4, 5-7, and ≥8 mm for largest stone diameter; and 0-8, 9-78, 79-280, and ≥281 mm(3) for TSV; 48% had bilateral stones. The hazard ratios (HRs) for symptomatic event was 1.30 (P <.001) for the number of stones per quartile, 1.26 (P <.001) for largest stone diameter per quartile, 1.38 (P <.001) for TSV per quartile, and 1.80 (P <.001) for bilateral stones. On multivariate analysis, only TSV was an independent predictor of symptomatic events (HR, 1.35 per quartile; P = .01). This risk of events with TSV was also independent of demographics, urine chemistries, and stone composition. Among the 53 patients with interim events between CT scans, a rapid increase in TSV between CT scans (>570 mm(3) per year) predicted subsequent events (HR, 2.8; P = .05).

conclusionAutomated TSV is more predictive of symptomatic events than manual methods for quantifying stone burden on CT scan.

Indexed as

Asymptomatic DiseasesTomography, X-Ray ComputedFemaleHumansKidney CalculiMaleMiddle AgedPrognosis

Identifiers

PMID25440821
PMCPMC4275381

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.