ArticleThe Plant journal : for cell and molecular biology2015
Urea retranslocation from senescing Arabidopsis leaves is promoted by DUR3-mediated urea retrieval from leaf apoplast.
Article in The Plant journal : for cell and molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Tree type-specific endophytic bacterial assembly and function in senescing leaves and needles in temperate forests of Central Europe.BMC plant biology · 2026Article
- Gene expression through comparative transcriptome analysis unravels the molecular mechanisms of fertilizer-induced hormonal regulation and leaf senescence in maize for enhanced yield in semiarid regions.BMC plant biology · 2025Article
- Structural basis of urea transport by Arabidopsis thaliana DUR3.Nature communications · 2025Article
- Metabolic and Antioxidant Responses of Different Control Methods to the Interaction ofInternational journal of molecular sciences · 2024Article
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- Dissecting the cotranscriptome landscape of plants and their microbiota.EMBO reports · 2022Article
- Molecular mechanisms of resistance toFrontiers in plant science · 2022Article
- Application of Nitrate, Ammonium, or Urea Changes the Concentrations of Ureides, Urea, Amino Acids and Other Metabolites in Xylem Sap and in the Organs of Soybean Plants (International journal of molecular sciences · 2021Article
- The urea transporter DUR3 is differentially regulated by abiotic and biotic stresses in coffee plants.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Sink/Source Balance of Leaves Influences Amino Acid Pools and Their Associated Metabolic Fluxes in Winter Oilseed Rape (Metabolites · 2020Article
- An Age-Dependent Sequence of Physiological Processes Defines Developmental Root Senescence.Plant physiology · 2019Article
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- Changes in nitrogen availability lead to a reprogramming of pyruvate metabolism.BMC plant biology · 2018Article
- Darkened Leaves Use Different Metabolic Strategies for Senescence and Survival.Plant physiology · 2018Article
- Metabolomics of laminae and midvein during leaf senescence and source-sink metabolite management in Brassica napus L. leaves.Journal of experimental botany · 2018Article
- Primed primary metabolism in systemic leaves: a functional systems analysis.Scientific reports · 2018Article
- Effect of soybean ureases on seed germination and plant development.Genetics and molecular biology · 2017Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In plants, urea derives either from root uptake or protein degradation. Although large quantities of urea are released during senescence, urea is mainly seen as a short-lived nitrogen (N) catabolite serving urease-mediated hydrolysis to ammonium. Here, we investigated the roles of DUR3 and of urea in N remobilization. During natural leaf senescence urea concentrations and DUR3 transcript levels showed a parallel increase with senescence markers like ORE1 in a plant age- and leaf age-dependent manner. Deletion of DUR3 decreased urea accumulation in leaves, whereas the fraction of urea lost to the leaf apoplast was enhanced. Under natural and N deficiency-induced senescence DUR3 promoter activity was highest in the vasculature, but was also found in surrounding bundle sheath and mesophyll cells. An analysis of petiole exudates from wild-type leaves revealed that N from urea accounted for >13% of amino acid N. Urea export from senescent leaves further increased in ureG-2 deletion mutants lacking urease activity. In the dur3 ureG double insertion line the absence of DUR3 reduced urea export from leaf petioles. These results indicate that urea can serve as an early metabolic marker for leaf senescence, and that DUR3-mediated urea retrieval contributes to the retranslocation of N from urea during leaf senescence.
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