ArticleBritish journal of pharmacology2015
Chronic exercise normalizes changes in Cav 1.2 and KCa 1.1 channels in mesenteric arteries from spontaneously hypertensive rats.
Article in British journal of pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Cardiovascular effects of exercise training in spontaneously hypertensive rats: A systematic review and meta-analysis.Physiological reports · 2026Pooled it
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- BK Channels in Tail Artery Vascular Smooth Muscle Cells of Normotensive (WKY) and Hypertensive (SHR) Rats Possess Similar Calcium Sensitivity But Different Responses to the Vasodilator Iloprost.International journal of molecular sciences · 2024Article
- SMIT (Sodium-Myo-Inositol Transporter) 1 Regulates Arterial Contractility Through the Modulation of Vascular Kv7 Channels.Arteriosclerosis, thrombosis, and vascular biology · 2020Article
- Role of the Balance of Akt and MAPK Pathways in the Exercise-Regulated Phenotype Switching in Spontaneously Hypertensive Rats.International journal of molecular sciences · 2019Article
- Prenatal hypoxia plus postnatal high-fat diet exacerbated vascular dysfunction via up-regulated vascular Cav1.2 channels in offspring rats.Journal of cellular and molecular medicine · 2019Article
- Aerobic exercise enhanced endothelium-dependent vasorelaxation in mesenteric arteries in spontaneously hypertensive rats: the role of melatonin.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Downregulation of L-Type Voltage-Gated CaJournal of the American Heart Association · 2018Article
- BKHypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Epigenetic regulation of L-type voltage-gated CaHypertension research : official journal of the Japanese Society of Hypertension · 2017Article
- A Role of BK Channel in Regulation of CaBiophysical journal · 2017Article
- Isometric Stretch Alters Vascular Reactivity of Mouse Aortic Segments.Frontiers in physiology · 2017Article
- Exercise intensity-dependent reverse and adverse remodeling of voltage-gated Ca(2+) channels in mesenteric arteries from spontaneously hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Exercise may be detrimental in hypertension: too much of a good thing!Hypertension research : official journal of the Japanese Society of Hypertension · 2015Article
- Microvascular Function and Exercise Training: Functional Implication of Nitric Oxide Signaling and Ion Channels.Pulse (Basel, Switzerland)Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeRegular physical activity is an effective non-pharmacological therapy for prevention and control of hypertension. However, the underlying mechanisms are not fully understood. Accumulating evidence shows that the elevated vascular tone in hypertension is a consequence of the 'ion channel remodelling' that occurs during sustained high BP. The present study investigated the effects of aerobic exercise on the electrical remodelling of L-type Ca(2+) (Cav 1.2) and large-conductance Ca(2+) -activated K(+) (KCa 1.1) channels in mesenteric arteries (MAs) from spontaneously hypertensive rats (SHRs). EXPERIMENTAL APPROACH: SHRs and normotensive (Wistar-Kyoto) rats were subjected to aerobic training or kept sedentary, and vascular mechanical and functional properties were evaluated. KEY
resultsExercise did not affect the heart weight, but reduced the heart rate and body weight in SHR. In mesenteric arterial myocytes, exercise normalized the increased Cav 1.2 and KCa 1.1 current density in SHRs. Exercise also ameliorated the increased open probability and mean open time of the single KCa 1.1 channel in hypertension. The isometric contraction study revealed that both nifedipine (Cav 1.2 channel blocker) and NS11021 (KCa 1.1 channel activator) induced concentration-dependent vasorelaxation in MAs precontracted with noradrenaline. Exercise normalized the increased sensitivity of tissues to nifedipine and NS11021 in SHR. Furthermore, protein expression of the Cav 1.2 α1C -subunit together with the KCa 1.1 α- and β1-subunit was significantly increased in SHRs; and exercise ameliorated these molecular alterations in hypertension. CONCLUSIONS AND IMPLICATIONS: Chronic exercise reduces BP and restores vascular function in MAs from SHR, which might be related to the correction of the Cav 1.2 and KCa 1.1 channel remodelling during hypertension.
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