ArticleMolecular oral microbiology2015
A YadA-like autotransporter, Hag1 in Veillonella atypica is a multivalent hemagglutinin involved in adherence to oral streptococci, Porphyromonas gingivalis, and human oral buccal cells.
Article in Molecular oral microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 49 citations in OpenAlex.
- Microbiome in adult severe caries and cross-kingdom biofilms validation.Clinical oral investigations · 2026Article
- Establishment of a HicA toxin-based counterselection system for markerless genetic engineering in Veillonella atypica OK5.BMC microbiology · 2026Article
- Identification of interbacterial adhesion between oral Schaalia species and streptococcal serine-rich repeat glycoproteins.FEMS microbiology letters · 2026Article
- CRISPR spacer profiling and prophage mining reveal diverse bacteriophages associated withJournal of oral microbiology · 2026Article
- Comparative analysis of the microbiota in gingival crevicular fluid from peri-implantitis and periodontitis using 16 S ribosomal RNA gene amplicon sequencing: a cross-sectional study.BMC oral health · 2025Article
- Causal association between oral microbiota and oral cancer: a mendelian randomization study.Scientific reports · 2025Article
- Periodontal Pathogens Correlate with Rheumatoid Arthritis Disease Parameters: A Systematic Review Based on Clinical Studies.Dentistry journal · 2025Review
- Article
- Meta-omics reveals subgingival plaque reconstruction dynamics.Journal of oral microbiology · 2025Article
- Identification ofmBio · 2024Article
- Development of a small shuttle plasmid for use in oral Veillonella and initial appraisal of potential for fluorescence-based applications.Letters in applied microbiology · 2024Article
- Supragingival microbiome variations and the influence ofJournal of oral microbiology · 2024Article
- The polymicrobial pathogenicity ofFrontiers in oral health · 2024Article
- Social networking at the microbiome-host interface.Infection and immunity · 2023Review
- Numerical and experimental investigation of multi-species bacterial co-aggregation.Scientific reports · 2023Article
- Comparison of antibacterial and antibiofilm activity of bioactive glass compounds S53P4 and 45S5.BMC microbiology · 2022Article
- Tumor tissue-specific bacterial biomarker panel for colorectal cancer: Bacteroides massiliensis, Alistipes species, Alistipes onderdonkii, Bifidobacterium pseudocatenulatum, Corynebacterium appendicis.Archives of microbiology · 2022Article
- Veillonellaceae family members uniquely alter the cervical metabolic microenvironment in a human three-dimensional epithelial model.NPJ biofilms and microbiomes · 2021Article
- Veillonellae: Beyond Bridging Species in Oral Biofilm Ecology.Frontiers in oral health · 2021Review
- Autotransporters Drive Biofilm Formation and Autoaggregation in the Diderm Firmicute Veillonella parvula.Journal of bacteriology · 2020Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Dental biofilm development is a sequential process, and adherence between microbes and the salivary pellicle (adhesion) as well as among different microbes (co-adhesion or coaggregation) plays a critical role in building a biofilm community. The Veillonella species are among the most predominant species in the oral cavity and coaggregate with many initial, early, middle, and late colonizers. Similar to oral fusobacteria, they are also considered bridging species in biofilm development. However, the mechanism of this ability has yet to be reported, due to the previous lack of a genetic transformation system in the entire genus. In this study, we used our recently discovered transformable Veillonella strain, Veillonella atypica OK5, to probe the mechanism of coaggregation between Veillonella species and other oral bacteria. By insertional inactivation of all eight putative hemagglutinin genes, we identified one gene, hag1, which is involved in V. atypica coaggregation with the initial colonizers Streptococcus gordonii, Streptococcus oralis and Streptococcus cristatus, and the periodontal pathogen Porphyromonas gingivalis. The hag1 mutant also abolished adherence to human buccal cells. Inhibition assays using various chemical or physiological treatments suggest different mechanisms being involved in coaggregation with different partners. The entire hag1 gene was sequenced and shown to be the largest known bacterial hemagglutinin gene.
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