Evidence map›Paper›PMID 25440327›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2015

Increased pulsatility of the intracranial blood flow spectral waveform on transcranial Doppler does not point to peripheral arterial disease in stroke patients.

Kristian Barlinn, Stanislava Kolieskova, Reza Bavarsad Shahripour, Jessica Kepplinger, Amelia K Boehme, Timo Siepmann, Volker Puetz, Ulf Bodechtel, William D Jordan, Andrei V Alexandrov

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In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Kristian BarlinnDepartment of Neurology, Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Alabama; Dresden University Stroke Center, Department of Neurology, University Hospital Carl Gustav Carus Dresden, University of Technology Dresden, Dresden, Germany. Electronic address: kristian.barlinn@uniklinikum-dresden.de.
Stanislava KolieskovaDepartment of Neurology, Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Alabama; International Clinical Research Centre, St. Anne's University Hospital, Brno, Czech Republic; Neurology Department, Masaryk University, Brno, Czech Republic.
Reza Bavarsad ShahripourDepartment of Neurology, Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Alabama.
Jessica KepplingerDresden University Stroke Center, Department of Neurology, University Hospital Carl Gustav Carus Dresden, University of Technology Dresden, Dresden, Germany.
Amelia K BoehmeDepartment of Epidemiology, School of Public Health, University of Alabama Hospital, Birmingham, Alabama.
Timo SiepmannDresden University Stroke Center, Department of Neurology, University Hospital Carl Gustav Carus Dresden, University of Technology Dresden, Dresden, Germany.
Volker PuetzDresden University Stroke Center, Department of Neurology, University Hospital Carl Gustav Carus Dresden, University of Technology Dresden, Dresden, Germany.
Ulf BodechtelDresden University Stroke Center, Department of Neurology, University Hospital Carl Gustav Carus Dresden, University of Technology Dresden, Dresden, Germany.
William D JordanDepartment of Vascular Surgery, University of Alabama Hospital, Birmingham, Alabama.
Andrei V AlexandrovDepartment of Neurology, Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Alabama; Department of Neurology, The University of Tennessee Health Science Center, Memphis, Tennessee.
University Hospital Carl Gustav Carus · DEUniversity of Alabama at Birmingham Hospital · USMasaryk University · CZUniversity of Tennessee Health Science Center · US

Funding

NEUROEPIDEMIOLOGY TRAINING PROGRAMT32NS007153 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GU, YIAN, WILLEY, JOSHUA ZEBADIAH · 1987 to 2023
$6.2M
NINDS NIH HHS T32 NS007153
6 · The paper itself

Abstract

backgroundPeripheral arterial disease (PAD) is common in patients with acute cerebral ischemia. Indexes of resistance derived from the systolic and diastolic velocities are routinely used in diagnostic transcranial Doppler (TCD) to detect intracranial arterial disease. We sought to explore whether these indexes can predict the presence of PAD in acute cerebral ischemia.

methodsWe prospectively evaluated consecutive patients with acute cerebral ischemia. On TCD, peak-systolic and end-diastolic velocities in both middle cerebral and basilar arteries were manually measured to calculate pulsatility index (PI) and resistance index (RI). Increased resistance was defined as PI equal to 1.2 or more and RI equal to .75 or more. Ankle-brachial index (ABI) measurements were performed and an ABI equal to .9 or more was considered predictive of definite PAD.

resultsWe included 95 patients (45 male, 50 female) aged 66 ± 9 years with a median National Institutes Health Stroke Scale score of 3 (interquartile range, 8) points. The ABI was abnormal and consistent with definite PAD in 24 of 95 (25.3%; 95% confidence interval [CI], 16.4-34.2) patients. Increased PI did not differ among patients with and without PAD (20.8% vs. 28.2%, P = .60). Only 1 patient with PAD had increased RI as opposed to 4 patients without PAD (4.2% vs. 5.6%, P = 1.0). Increased PI was not found to be an independent predictor of PAD (odds ratio [OR], .68; 95% CI, .22-2.12; P = .51). Increases in both PI and RI independently predicted arterial hypertension (OR, 1.62; 95% CI, 1.19-2.21; P = .002 and OR, 3.20; 95% CI, 1.51-6.77; P = .002, respectively).

conclusionsOur findings indicate that PAD cannot be inferred from intracranial flow parameters predictive of arterial disease and risk factors such as hypertension among patients with acute cerebral ischemia.

Indexed as

Cerebrovascular CirculationAgedAnkle Brachial IndexAtrial FibrillationBrain IschemiaFemaleHumansIschemic Attack, TransientMaleMiddle AgedPeripheral Arterial DiseaseProspective StudiesRisk FactorsStrokeUltrasonography, Doppler, Transcranialintracranial diseaseperipheral arterial diseaseStroketranscranial Doppler

Identifiers

PMID25440327
PMCPMC4602393
OpenAlexW2080868369

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.