Evidence map›Paper›PMID 25440311›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2014

Repetitive behavior in 12-month-olds later classified with autism spectrum disorder.

Jed T Elison, Jason J Wolff, J Steven Reznick, Kelly N Botteron, Annette M Estes, Hongbin Gu, Heather C Hazlett, Adriane J Meadows, Sarah J Paterson, Lonnie Zwaigenbaum and 2 more

Abstract read
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
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  5. Review
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  7. Article
  8. Semi-Automated Multi-Label Classification of Autistic Mannerisms by Machine Learning on Post Hoc Skeletal Tracking.Autism research : official journal of the International Society for Autism Research · 2025
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  20. Patterns of Restricted and Repetitive Behaviors in Toddlers and Young Children with Autism Spectrum Disorder.Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatry · 2022
    Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jed T ElisonInstitute of Child Development at the University of Minnesota, Minneapolis. Electronic address: jtelison@umn.edu.
Jason J WolffCarolina Institute for Developmental Disabilities and the University of North Carolina (UNC) at Chapel Hill, NC.
J Steven ReznickUniversity of North Carolina at Chapel Hill.
Kelly N BotteronWashington University in St. Louis.
Annette M EstesUniversity of Washington, Seattle.
Hongbin GuCarolina Institute for Developmental Disabilities and the University of North Carolina (UNC) at Chapel Hill, NC.
Heather C HazlettCarolina Institute for Developmental Disabilities and the University of North Carolina (UNC) at Chapel Hill, NC.
Adriane J MeadowsCarolina Institute for Developmental Disabilities and the University of North Carolina (UNC) at Chapel Hill, NC.
Sarah J PatersonDr. Paterson is with the Children's Hospital of Philadelphia.
Lonnie ZwaigenbaumDr. Zwaigenbaum is with the University of Alberta, Edmonton, Alberta, Canada.
Joseph PivenCarolina Institute for Developmental Disabilities and the University of North Carolina (UNC) at Chapel Hill, NC.
Infant Brain Imaging Study (IBIS) Network

Funding

Cellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6M
UNC MRDD Research CenterP30HD003110 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PIVEN, JOSEPH · 1985 to 2012
$28.7M
Postdoctoral Research in Neurodevelopmental DisordersT32HD040127 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN D PHILPOT, Mark D Shen · 2001 to 2026
$8.5M
Human Development: Interdisiplinary Research TrainingT32HD007376 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BELGER, AYSENIL, PROPPER, CATHI BARBRA · 1988 to 2020
$8.0M
Preclinical CoreU54HD079124 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, YUN · 2013 to 2019
$8.0M
NICHD NIH HHS 5-T32-HD007376NICHD NIH HHS HD055741-S1NICHD NIH HHS P30 HD003110NICHD NIH HHS P30 HD03110NICHD NIH HHS R01 HD055741NICHD NIH HHS T32 HD007376NICHD NIH HHS T32 HD040127NICHD NIH HHS T32 HD40127NICHD NIH HHS U54 HD079124
6 · The paper itself

Abstract

objectiveAs compared to the utility of early emerging social communicative risk markers for predicting a later diagnosis of autism spectrum disorder (ASD), less is known about the relevance of early patterns of restricted and repetitive behaviors. We examined patterns of stereotyped motor mannerisms and repetitive manipulation of objects in 12-month-olds at high and low risk for developing ASD, all of whom were assessed for ASD at 24 months.

methodObservational coding of repetitive object manipulation and stereotyped motor behaviors in digital recordings of the Communication and Symbolic Behavior Scales was conducted using the Repetitive and Stereotyped Movement Scales for 3 groups of 12-month-olds: low-risk infants (LR, n = 53); high-familial-risk infants who did not meet diagnostic criteria for ASD at 24 months (HR-negative, n = 75); and high-familial-risk infants who met diagnostic criteria for ASD at 24 months (HR-ASD, n = 30).

resultsThe HR-ASD group showed significantly more stereotyped motor mannerisms than both the HR-negative group (p = .025) and the LR group (p = .001). The HR-ASD and HR-negative groups demonstrated statistically equivalent repetitive object manipulation scores (p = .431), and both groups showed significantly more repetitive object manipulation than the LR group (p < .040). Combining the motor and object stereotypy scores into a Repetitive and Stereotyped Movement Scales (RSMS) composite yielded a disorder-continuum effect such that each group was significantly different from one another (LR < HR-negative < HR-ASD).

conclusionThese results suggest that targeted assessment of repetitive behavior during infancy may augment early ASD identification efforts.

Indexed as

Stereotyped BehaviorChild Development Disorders, PervasiveCohort StudiesFemaleGenetic Predisposition to DiseaseHumansInfantLongitudinal StudiesMaleProspective StudiesRisk Factorsautismdevelopmentinfant siblingsmotor stereotypiesrepetitive behavior

Identifiers

PMID25440311
PMCPMC4254502

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.