Trial reportJournal of the American College of Cardiology2014
Impact of initial shunt type on cardiac size and function in children with single right ventricle anomalies before the Fontan procedure: the single ventricle reconstruction extension trial.
Trial report in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00115934 (Trial of Right Ventricular Versus Modified Blalock-Taussig Shunt in Infants With Single Ventricle Defect Undergoing Staged Reconstruction), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial of Right Ventricular Versus Modified Blalock-Taussig Shunt in Infants With Single Ventricle Defect Undergoing Staged Reconstruction (A Trial Conducted by the Pediatric Heart Network)
Who cites it
19 citing papers in PubMed.
- Cardiac Magnetic Resonance Imaging to Determine Single Ventricle Function in a Pediatric Population is Feasible in a Large Trial Setting: Experience from the Single Ventricle Reconstruction Trial Longitudinal Follow up.Pediatric cardiology · 2023Trial
- Impact of Initial Shunt Type on Echocardiographic Indices in Children After Single Right Ventricle Palliations.Circulation. Cardiovascular imaging · 2019Trial
- The Impact of the Left Ventricle on Right Ventricular Function and Clinical Outcomes in Infants with Single-Right Ventricle Anomalies up to 14 Months of Age.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2018Trial
- Factors affecting Fontan length of stay: Results from the Single Ventricle Reconstruction trial.The Journal of thoracic and cardiovascular surgery · 2016Trial
- Effect of Valved Versus Non-valved Conduits on Ventricular Size and Function in Stage I Palliation for Hypoplastic Left Heart Syndrome.Pediatric cardiology · 2026Article
- Right Ventricular Remodeling and Function in Hypoplastic Left Heart Syndrome.JACC. Advances · 2024Review
- Morphology of the native ascending aorta after the Norwood procedure for aortic atresia: impact on survival and right ventricular dysfunction.Interdisciplinary cardiovascular and thoracic surgery · 2024Article
- Association of Digoxin With Preserved Echocardiographic Indices in the Interstage Period: A Possible Mechanism to Explain Improved Survival?Journal of the American Heart Association · 2021Article
- Longitudinal Assessment of Right Ventricular Function in Hypoplastic Left Heart Syndrome.Pediatric cardiology · 2021Article
- Decreased right ventricular longitudinal strain in children with hypoplastic left heart syndrome during staged repair and follow-up: does it have implications in clinically stable patients?The international journal of cardiovascular imaging · 2020Article
- Neo-aortic insufficiency late after staged reconstruction for hypoplastic left heart syndrome: impact of differences in initial palliative procedures.Heart and vessels · 2019Article
- Hypoplastic left heart syndrome [HLHS]: treatment options in present era.Indian journal of thoracic and cardiovascular surgery · 2019Review
- Heart failure after the Norwood procedure: An analysis of the Single Ventricle Reconstruction Trial.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2018Article
- Blood-threshold CMR volume analysis of functional univentricular heart.La Radiologia medica · 2018Article
- Association of Shunt Type With Arrhythmias After Norwood Procedure.The Annals of thoracic surgery · 2018Observational
- Histone deacetylase adaptation in single ventricle heart disease and a young animal model of right ventricular hypertrophy.Pediatric research · 2017Article
- Hypoplastic left heart syndrome: from comfort care to long-term survival.Pediatric research · 2017Review
- Variable Myocardial Response to Load Stresses in Infants with Single Left Ventricular Anatomy: Influence of Initial Physiology and Surgical Palliative Strategy.Pediatric cardiology · 2016Article
- Maladaptive aortic properties after the Norwood procedure: An angiographic analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial.The Journal of thoracic and cardiovascular surgery · 2016Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundIn children with single right ventricular (RV) anomalies, changes in RV size and function may be influenced by shunt type chosen at the time of the Norwood procedure.
objectivesThe study sought to identify shunt-related differences in echocardiographic findings at 14 months and ≤6 months pre-Fontan in survivors of the Norwood procedure.
methodsWe compared 2-dimensional and Doppler echocardiographic indices of RV size and function, neo-aortic and tricuspid valve annulus dimensions and function, and aortic size and patency at 14.1 ± 1.2 months and 33.6 ± 9.6 months in subjects randomized to a Norwood procedure using either the modified Blalock-Taussig shunt (MBTS) or right ventricle to pulmonary artery shunt (RVPAS).
resultsAcceptable echocardiograms were available at both time points in 240 subjects (114 MBTS, 126 RVPAS). At 14 months, all indices were similar between shunt groups. From the 14-month to pre-Fontan echocardiogram, the MBTS group had stable indexed RV volumes and ejection fraction, while the RVPAS group had increased RV end-systolic volume (p = 0.004) and decreased right ventricular ejection fraction (RVEF) (p = 0.004). From 14 months to pre-Fontan, the treatment groups were similar with respect to decline in indexed neo-aortic valve area, >mild neo-aortic valve regurgitation (<5% at each time), indexed tricuspid valve area, and ≥moderate tricuspid valve regurgitation (<20% at each time).
conclusionsInitial Norwood shunt type influences pre-Fontan RV remodeling during the second and third years of life in survivors with single RV anomalies, with greater RVEF deterioration after RVPAS. Encouragingly, other indices of RV function remain stable before Fontan regardless of shunt type. (Comparison of Two Types of Shunts in Infants with Single Ventricle Defect Undergoing Staged Reconstruction-Pediatric Heart Network; NCT00115934).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.