Evidence map›Paper›PMID 25440052›Full record

ArticleCell metabolism2014

Linking DNA damage, NAD(+)/SIRT1, and aging.

Leonard Guarente

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cell metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. A sustained NADBioactive materials · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. NADCell & bioscience · 2023
    Review
  6. Article
  7. Article
  8. NADNAR cancer · 2021
    Article
  9. Review
  10. NADSignal transduction and targeted therapy · 2021
    Review
  11. Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  12. Review
  13. Article
  14. Article
  15. Sirtuins and Accelerated Aging in Scleroderma.Current rheumatology reports · 2018
    Review
  16. Article
  17. Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer?Journal of diabetes and its complications · 2017
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Leonard GuarenteNovartis Professor of Biology, Director of the Glenn Labs for the Science of Aging, and Affiliate of the Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA. Electronic address: leng@mit.edu.

Funding

MOLECULAR STUDY OF YEAST SGS1 AND RDNA CIRCLES IN AGINGR01AG015339 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GUARENTE, LEONARD P · 1999 to 2014
$5.5M
NIA NIH HHS R01 AG015339
6 · The paper itself

Abstract

Diseases due to DNA damage repair machinery defects can resemble premature aging. In this issue of Cell Metabolism, Scheibye-Knudsen et al. (2014) demonstrate that increasing NAD(+) levels may reverse the inactivation of Sirt1 and mitochondrial defects in Cockayne Syndrome B that stem from nuclear NAD(+) depletion by the DNA repair protein PARP.

Indexed as

Diet, High-FatAging, PrematureAnimalsCockayne SyndromeHumansNADSirtuin 1NADSirtuin 1

Identifiers

PMID25440052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.