ArticleThe journal of allergy and clinical immunology. In practice
Optimum predictors of childhood asthma: persistent wheeze or the Asthma Predictive Index?
Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Risk Factors in Preschool Children for Predicting Asthma During the Preschool Age and the Early School Age: a Systematic Review and Meta-Analysis.Current allergy and asthma reports · 2017Pooled it
- A systematic review of predictive models for asthma development in children.BMC medical informatics and decision making · 2015Pooled it
- Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Impact of antimicrobial exposure at delivery and siblings on early Bifidobacterium succession and allergy development up to 24 months of age.BMC microbiology · 2025Article
- Artificial intelligence and wheezing in children: where are we now?Frontiers in medicine · 2024Review
- Maternal antibiotic exposure and childhood allergies: The Japan Environment and Children's Study.The journal of allergy and clinical immunology. Global · 2023Article
- Article
- Early Prediction of Asthma.Journal of clinical medicine · 2023Review
- Perinatal Characteristics and the Sensitization to Cow Milk, Egg Whites and Wheat in Children up to 3 Years of Age.Children (Basel, Switzerland) · 2023Article
- Persistent Asthma at School Age: Associated Factors in Preschool Children with Asthma.Children (Basel, Switzerland) · 2022Article
- Allergic Rhinitis and House Dust Mite Sensitization Determine Persistence of Asthma in Children.Indian journal of pediatrics · 2022Article
- Defining pediatric asthma: phenotypes to endotypes and beyond.Pediatric research · 2021Review
- Early Life Wheeze and Risk Factors for Asthma-A Revisit at Age 7 in the GEWAC-Cohort.Children (Basel, Switzerland) · 2021Article
- Asthma-prone areas modeling using a machine learning model.Scientific reports · 2021Article
- Personalized prediction of early childhood asthma persistence: A machine learning approach.PloS one · 2021Article
- Preschool Wheezing: Trajectories and Long-Term Treatment.Frontiers in pediatrics · 2020Review
- Wheezing in children: Approaches to diagnosis and management.International journal of pediatrics & adolescent medicine · 2019Review
- A Pediatric Asthma Risk Score to better predict asthma development in young children.The Journal of allergy and clinical immunology · 2019Article
- Use of Symptoms Scores, Spirometry, and Other Pulmonary Function Testing for Asthma Monitoring.Frontiers in pediatrics · 2019Review
- Predicting Asthma Using Clinical Indexes.Frontiers in pediatrics · 2019Review
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10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe Asthma Predictive Index (API) and persistent wheezing phenotypes are associated with childhood asthma, but previous studies have not assessed their ability to predict objectively confirmed asthma.
objectiveTo determine whether the University of Cincinnati API Index (ucAPI) and/or persistent wheezing at age 3 can accurately predict objectively confirmed asthma at age 7.
methodsData from the Cincinnati Childhood Allergy and Air Pollution Study, a high-risk prospective birth cohort, was used. Asthma was defined as parent-reported or physician-diagnosed asthma objectively confirmed by a change in FEV1 of ≥12% after bronchodilator or a positive methacholine challenge (PC20 ≤ 4 mg/mL); or as prior treatment with daily asthma controller medication(s). Multivariate logistic regression was used to investigate the relationship between confirmed asthma at age 7 and a positive ucAPI (adapted and modified from prior published API definitions) and persistent wheezing at age 3.
resultsAt age 7, 103 of 589 children (17.5%) satisfied the criteria for asthma. Confirmed asthma at age 7 was significantly associated with a positive ucAPI (adjusted odds ratio [aOR] 13.3 [95% CI, 7.0-25.2]; P < .01) and the persistent wheezing phenotype (aOR 9.8 [95% CI, 4.9-19.5]; P < .01) at age 3. Allergic persistent wheezing was associated with a significantly higher risk of asthma (aOR 10.4 [95% CI, 4.1-26.0]; P < .01) than nonallergic persistent wheezing (aOR 5.4 [95% CI, 2.04-14.06]; P < .01).
conclusionBoth a positive ucAPI and persistent wheeze at age 3 were associated with objectively confirmed asthma at age 7; however, the highest risk was associated with ucAPI. These results demonstrate the ucAPI as a clinically useful tool for predicting future asthma in school-age children.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.